{"product_id":"ara-290","title":"Ara-290","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\u003cdetails open=\"\" class=\"peptide-details\"\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cdiv\u003eARA-290 is a synthetic research peptide, an 11-amino acid engineered to mimic the three-dimensional structure of the helix B surface domain of erythropoietin (EPO). ARA-290 peptide is non-erythropoietic, designed to retain neuroprotective and anti-inflammatory activities while eliminating hematopoietic function. This Peptide has received Orphan Drug Designation from FDA for treatment of neuropathic pain in sarcoidosis patients and has been investigated for retinal diseases.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eARA-290 exerts its effects through selective, high-affinity binding to the Innate Repair Receptor (IRR)—a heterodimeric receptor complex composed of the erythropoietin receptor (EPOR) and the β-common receptor (βcR\/CD131). This receptor is typically expressed at low levels in healthy tissues but is upregulated in response to injury, inflammation, or metabolic stress. By selectively activating the IRR without interacting with the erythropoietic EPO-R homodimer, ARA-290 triggers a cascade of intracellular signaling events that collectively suppress inflammation, inhibit apoptosis, and promote tissue regeneration. Key downstream pathways include JAK2\/STAT, PI3K\/Akt, and inhibition of the NF-κB inflammatory pathway.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuropathic Pain and Neuropathy:\u003c\/strong\u003e Investigated for the treatment of neuropathic pain in sarcoidosis and diabetes, with clinical trials demonstrating dose-dependent reduction of allodynia and suppression of spinal microglia responses.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIschemic Stroke and Neuroprotection:\u003c\/strong\u003e Studied for brain tissue protection in cerebral ischemic stroke models, providing neuroprotective effects via the β-common receptor without causing erythropoiesis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Control and Type 2 Diabetes:\u003c\/strong\u003e Employed in research to evaluate improvement of metabolic control and neuropathic symptoms in patients with type 2 diabetes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInflammatory and Autoimmune Diseases:\u003c\/strong\u003e Investigated in models of experimental colitis, experimental autoimmune encephalomyelitis, and renal allograft injury for its anti-inflammatory and tissue-protective properties.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCisplatin-Induced Nephrotoxicity:\u003c\/strong\u003e Studied for protective effects through anti-apoptotic, anti-inflammatory, and antioxidant mechanisms.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 1208243-50-8\u003cbr\u003e\u003cstrong\u003ePubChem CID:\u003c\/strong\u003e 91810664\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₅₁H₈₄N₁₆O₂₁\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 1,257.31 g\/mol\u003cbr\u003e\u003cstrong\u003eSequence:\u003c\/strong\u003e Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH (Pyr = pyroglutamic acid)\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99%\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e","brand":"yuansensetech","offers":[{"title":"RA 10mg","offer_id":52038353191202,"sku":"RA10","price":88.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/Ara-290.jpg?v=1783741681","url":"https:\/\/yuansensepeptide.com\/products\/ara-290","provider":"Yuansensetech™","version":"1.0","type":"link"}