{"product_id":"botulinum-toxin","title":"Botulinum Toxin","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\n\u003cdetails class=\"peptide-details\" open\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eBotulinum toxin (BoNT) is a family of neurotoxic proteins produced by neurotoxigenic strains of the anaerobic, spore-forming bacteria of the genus Clostridium (including Clostridium botulinum, C. butyricum, C. baratii, and C. argentinensis). As one of the most potent toxins known, BoNT has been successfully harnessed as a versatile therapeutic agent since pioneering work in the 1970s for strabismus treatment. The protein exists in seven distinct serotypes (A through G), with human tissue being susceptible to types A, B, E, F, and G. The active toxin in all serotypes is a ~150 kDa molecule, which in many commercial preparations forms a larger protein complex of ~900 kDa with accessory proteins that stabilize the compound. The compound has been FDA-approved for numerous therapeutic and aesthetic indications.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eBotulinum toxin exerts its effects through a multi-step process at the presynaptic cholinergic nerve terminal. Following injection, the toxin's heavy chain mediates high-affinity binding to the nerve terminal and subsequent endocytosis into an intracellular compartment. Once internalized, the light chain (a zinc-dependent metalloprotease) is translocated into the cytosol. There, it specifically cleaves SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) proteins—critical components for synaptic vesicle fusion. Different serotypes target distinct SNARE proteins: type A cleaves SNAP-25, while type B cleaves VAMP (synaptobrevin). This cleavage effectively inhibits the fusion of acetylcholine-containing vesicles with the cell membrane, thereby blocking neurotransmitter release at the neuromuscular junction and inducing temporary, controlled muscle weakening or paralysis. This action is reversible, with effects typically noticed in 1–3 days, peaking in 1–4 weeks, and lasting an average of 3–4 months.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuromuscular Disorders:\u003c\/strong\u003e Investigated for the treatment of movement disorders including cervical dystonia, spastic conditions, blepharospasm, and strabismus.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eChronic Pain and Migraine:\u003c\/strong\u003e Studied for its efficacy in managing chronic migraine, neuropathic pain, and other pain conditions by modulating neurotransmitter activity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUrological and Autonomic Disorders:\u003c\/strong\u003e Employed as an effective therapy for overactive bladder and hyperhidrosis (excessive sweating).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTissue Regeneration and Repair:\u003c\/strong\u003e Explored for promoting vascular effects, nerve regeneration, and bone healing, highlighting its potential in regenerative medicine.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCosmetic Dermatology:\u003c\/strong\u003e Utilized for the temporary improvement of moderate-to-severe dynamic facial lines, such as glabellar lines and crow's feet.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 93384-43-1 (Type A); 93384-44-2 (Type B)\u003cbr\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e ~150 kDa (active neurotoxin); ~900 kDa (neurotoxin complex)\u003cbr\u003e\n\u003cstrong\u003ePotency:\u003c\/strong\u003e Expressed in Units specific to each preparation (e.g., Allergan Units, Speywood Units); units are not interchangeable between different products\u003cbr\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e Batch-dependent; refer to Certificate of Analysis\u003cbr\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized or vacuum-dried powder for reconstitution\u003cbr\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light. Upon reconstitution, use promptly or store per manufacturer's instructions; avoid repeated freeze-thaw cycles\u003cbr\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile, preservative-free saline (0.9% sodium chloride) for injection; prepare working solutions per laboratory or clinical protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n","brand":"yuansensetech","offers":[{"title":"XT100","offer_id":52038354207010,"sku":"XT100","price":196.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/Botulinumtoxin.jpg?v=1783741707","url":"https:\/\/yuansensepeptide.com\/products\/botulinum-toxin","provider":"Yuansensetech™","version":"1.0","type":"link"}