{"product_id":"cagrilintide","title":"Cagrilintide","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eCagrilintide (AM833; NN0174-0833) is a novel, long-acting acylated analogue of the endogenous satiety hormone amylin. It functions as a dual agonist of the amylin receptor (AMYR) and the calcitonin G protein-coupled receptor (CTR). This unique mechanism allows it to significantly reduce body weight and food intake, making it a valuable tool for obesity and related metabolic disorder research. The compound is being developed for once-weekly subcutaneous administration, and is currently being investigated in clinical trials both as a monotherapy and in a fixed-dose combination with the GLP-1 receptor agonist semaglutide (CagriSema).\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eCagrilintide exerts its effects by binding to and activating amylin and calcitonin receptors in key brain regions involved in appetite control, such as the area postrema and hypothalamus. This activation reduces food intake and promotes weight loss through central and peripheral mechanisms. As a long-acting analogue, it has a significantly extended half-life compared to traditional amylin analogues, reducing the need for frequent dosing.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eObesity and Metabolic Research:\u003c\/strong\u003e Employed as a tool to study appetite regulation, energy balance, and weight loss mechanisms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eType 2 Diabetes:\u003c\/strong\u003e Investigated for its potential to improve glycemic control and metabolic parameters, particularly in combination with other agents.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCombination Therapy Studies:\u003c\/strong\u003e Used to explore the synergistic effects of dual amylin\/calcitonin receptor agonism with GLP-1 receptor activation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 1415456-99-3\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₁₉₄H₃₁₂N₅₄O₅₉S₂\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 4,409.01 g\/mol\u003cbr\u003e\u003cstrong\u003eSequence:\u003c\/strong\u003e (Eicosanedioic acid-γ-Glu)-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Pro-NH₂ (Disulfide bridge: Cys³-Cys⁸)\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99%\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e White to off-white lyophilized powder\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e","brand":"yuansensetech","offers":[{"title":"CGL 5mg","offer_id":52038354141474,"sku":"CGL5","price":175.0,"currency_code":"USD","in_stock":true},{"title":"CGL 10mg","offer_id":52038354174242,"sku":"CGL10","price":239.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/Cagrilintide.jpg?v=1783741705","url":"https:\/\/yuansensepeptide.com\/products\/cagrilintide","provider":"Yuansensetech™","version":"1.0","type":"link"}