{"product_id":"cjc-1295-with-dac","title":"CJC-1295 With DAC","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\u003cdetails open=\"\" class=\"peptide-details\"\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eCJC-1295 with DAC (Drug Affinity Complex), also known as DAC:GRF, is a synthetic analogue of growth hormone-releasing hormone (GHRH) developed by ConjuChem Biotechnologies. It is a tetrasubstituted 30-amino acid peptide analogue of GHRH, featuring a C-terminal Drug Affinity Complex moiety—a lysine linker conjugated to maleimidopropionic acid (MPA)—that enables selective binding to circulating albumin. This DAC technology significantly extends the compound's half-life to approximately 6–8 days, compared to ~30 minutes for the non-DAC version, establishing it as a long-acting GHRH analogue.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eCJC-1295 with DAC exerts its effects by binding to the growth hormone-releasing hormone receptor (GHRH-R) on somatotroph cells in the anterior pituitary gland. This receptor activation stimulates the synthesis and release of endogenous growth hormone (GH) in a sustained manner. The Drug Affinity Complex moiety enables the peptide to covalently bind to serum albumin following subcutaneous administration, protecting it from enzymatic degradation and significantly prolonging its half-life. The compound incorporates four amino acid substitutions—D-Ala at position 2 (to prevent DPP-IV cleavage), Gln at position 8 (to reduce asparagine rearrangement), Ala at position 15 (to enhance bioactivity), and Leu at position 27 (to prevent methionine oxidation)—which further enhance its stability and bioactivity.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGrowth Hormone Axis Research:\u003c\/strong\u003e Employed to study sustained GH secretion dynamics, GHRH receptor signaling, and the physiological regulation of the hypothalamic-pituitary-somatotropic axis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic and Body Composition Studies:\u003c\/strong\u003e Investigated for its role in lipid metabolism, protein synthesis, and body composition regulation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEndocrinology:\u003c\/strong\u003e Utilized to evaluate the effects of prolonged GH elevation on IGF-1 production and metabolic parameters.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAging and Gerontology Research:\u003c\/strong\u003e Explored in the context of age-related metabolic decline and healthy aging.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\" open=\"\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 446262-90-4\u003cbr\u003e\u003cstrong\u003ePubChem CID:\u003c\/strong\u003e 16129620\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₁₆₅H₂₆₉N₄₇O₄₆\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 3,647.19–3,647.25 g\/mol\u003cbr\u003e\u003cstrong\u003eSequence:\u003c\/strong\u003e Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-LysLys(Maleimidopropionyl)-NH₂\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99%\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e","brand":"yuansensetech","offers":[{"title":"CD 5mg","offer_id":52038353223970,"sku":"CD5","price":232.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/CJC-1295WithDAC_b9faaca1-e333-49a3-bbfe-c11b67b60e48.jpg?v=1783741683","url":"https:\/\/yuansensepeptide.com\/products\/cjc-1295-with-dac","provider":"Yuansensetech™","version":"1.0","type":"link"}