{"product_id":"dermorphin","title":"Dermorphin","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\n\u003cdetails class=\"peptide-details\" open\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eDermorphin is a natural heptapeptide first isolated from the skin of South American frogs belonging to the genus Phyllomedusa, including Phyllomedusa sauvagei (Sauvage's leaf frog), Phyllomedusa hypochondrialis, and Phasmahyla jandaia. It is a potent and selective μ-opioid receptor (MOR) agonist with an amino acid sequence of Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂. Dermorphin is unique among vertebrate peptides in containing a D-amino acid residue (D-Ala at position 2), a structural feature that is critical for its biological activity and resistance to enzymatic degradation. The peptide exhibits opiate-like activity approximately 30–40 times more potent than morphine and has been extensively studied as a research tool for investigating opioid receptor signaling, analgesia, and neuropathic pain mechanisms.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eDermorphin exerts its effects by selectively binding to and activating the μ-opioid receptor (MOR), a G protein-coupled receptor (GPCR) expressed in the central and peripheral nervous systems. The presence of the D-Ala² residue is essential for high-affinity receptor binding and pharmacological activity. Upon receptor activation, dermorphin triggers intracellular signaling cascades involving G protein-mediated inhibition of adenylate cyclase, decreased cyclic AMP production, and modulation of ion channel activity, ultimately producing potent antinociceptive (analgesic) effects. Receptor internalization has been shown to contribute to dermorphin-mediated antinociception. Unlike many other opioid peptides, dermorphin demonstrates high selectivity for μ-opioid receptors with minimal interaction at δ- and κ-opioid receptors.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePain and Analgesia Research:\u003c\/strong\u003e Investigated as a potent analgesic agent in preclinical models of nociceptive and neuropathic pain.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOpioid Receptor Studies:\u003c\/strong\u003e Employed as a selective μ-opioid receptor agonist to study receptor binding, signaling pathways, internalization, and structure-activity relationships.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuropharmacology:\u003c\/strong\u003e Utilized to investigate opioid-mediated effects on locomotor activity, gastrointestinal transit, and central nervous system function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePeptide Analog Development:\u003c\/strong\u003e Used as a lead compound for the design and synthesis of novel non-narcotic analgesic peptides with improved pharmacokinetic profiles.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDrug Development:\u003c\/strong\u003e Studied in the development of comprehensive quality control approaches for synthetic opioid peptides.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 77614-16-5\u003cbr\u003e\n\u003cstrong\u003ePubChem CID:\u003c\/strong\u003e 5485199\u003cbr\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₄₀H₅₀N₈O₁₀\u003cbr\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 802.87 g\/mol\u003cbr\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH₂ (YaFGYPS-NH₂, where a = D-Ala)\u003cbr\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99%\u003cbr\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n","brand":"yuansensetech","offers":[{"title":"DR 5mg","offer_id":52038353846562,"sku":"DR5","price":75.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/Dermorphin.jpg?v=1783741697","url":"https:\/\/yuansensepeptide.com\/products\/dermorphin","provider":"Yuansensetech™","version":"1.0","type":"link"}