{"product_id":"dsip-delta-sleep-inducing-peptide","title":"DSIP（Delta Sleep-Inducing Peptide）","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\n\u003cdetails class=\"peptide-details\" open\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eDelta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide first isolated in the 1970s from the cerebral venous blood of rabbits during electrically induced sleep. It is a single, non-glycosylated polypeptide chain consisting of nine amino acids with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. Originally investigated for its sleep-promoting properties, DSIP has since been recognized as a neuromodulator with pleiotropic physiological effects. The compound is widely studied in neurobiology research for its effects on sleep architecture, stress responses, and neuroprotection.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eDSIP exerts its effects through multifaceted interactions with multiple neurotransmitter systems and intracellular signaling cascades. It potentiates GABA-activated currents in hippocampal and cerebellar neurons, enhancing GABAergic inhibition—a plausible mechanism for its sedative and anticonvulsant effects. DSIP also modulates the glutamatergic system, particularly through interaction with NMDA receptors. Additionally, it influences the endocrine system, affecting enzymatic activity of serotonin-N-acetyltransferase—a pineal enzyme with strong circadian rhythmicity. DSIP produces dose-dependent antinociceptive effects mediated via the opioid receptor system, and has demonstrated neuroprotective properties by protecting neurons from oxidative stress.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSleep Research:\u003c\/strong\u003e Investigated for its ability to promote delta (slow-wave) and spindle EEG patterns, enhancing the most restorative stage of sleep.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStress and HPA Axis Studies:\u003c\/strong\u003e Employed to study regulation of stress responses via the hypothalamic-pituitary-adrenal (HPA) axis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection:\u003c\/strong\u003e Studied for protecting neurons from oxidative stress, with potential applications in neurodegenerative disease research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePain and Analgesia Research:\u003c\/strong\u003e Used to investigate antinociceptive effects mediated through opioid receptor pathways.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntioxidant Research:\u003c\/strong\u003e Explored for its antioxidant properties, including modulation of catalase and superoxide dismutase (SOD) activities.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 62568-57-4 (free base)\u003cbr\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₃₅H₄₈N₁₀O₁₅\u003cbr\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 848.81 g\/mol (free base)\u003cbr\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE)\u003cbr\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99%\u003cbr\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n","brand":"yuansensetech","offers":[{"title":"DS 5mg","offer_id":52038353879330,"sku":"DS5","price":60.0,"currency_code":"USD","in_stock":true},{"title":"DS 15mg","offer_id":52038353912098,"sku":"DS15","price":138.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/DSIP_a801657f-e8e3-40ae-9a50-a30b812068c8.jpg?v=1783741698","url":"https:\/\/yuansensepeptide.com\/products\/dsip-delta-sleep-inducing-peptide","provider":"Yuansensetech™","version":"1.0","type":"link"}