{"product_id":"epithalon","title":"Epithalon","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eEpithalon (Epitalon) is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly (AEDG). It is a synthetic analog of epithalamin, a naturally occurring polypeptide extracted from the bovine pineal gland. The compound was developed at the St. Petersburg Institute of Bioregulation and Gerontology by Vladimir Khavinson and has been extensively studied for its geroprotective, neuroendocrine, and telomerase-activating properties.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eEpithalon functions as a precision epigenetic modulator rather than a direct enzymatic cofactor. Its primary mechanism involves the upregulation of telomerase activity, the enzyme responsible for maintaining and elongating telomeres—the protective caps at the ends of chromosomes that shorten with each cell division. Epithalon can penetrate the cell membrane and enter the nucleus, where it increases the transcriptional levels of neurogenesis-related genes such as Nestin and GAP43. The compound also stimulates evening melatonin production and normalizes circadian rhythms of cortisol production, while exerting antioxidant, neuroprotective, and antimutagenic effects through both specific and nonspecific mechanisms.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAging and Longevity Research:\u003c\/strong\u003e Investigated for its geroprotective effects through telomerase activation and telomere elongation in human somatic cells, with studies demonstrating increased lifespan in model organisms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroendocrine Regulation:\u003c\/strong\u003e Employed to study circadian rhythm restoration, melatonin synthesis modulation, and neuroprotection.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOncology Research:\u003c\/strong\u003e Studied for its inhibitory effects on spontaneous tumor development and carcinogenesis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCellular and Molecular Biology:\u003c\/strong\u003e Utilized as a tool to investigate peptide-mediated signaling pathways, telomerase regulation, and cellular senescence mechanisms.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 307297-39-8\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₁₄H₂₂N₄O₉\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 390.35 g\/mol\u003cbr\u003e\u003cstrong\u003eSequence:\u003c\/strong\u003e Ala-Glu-Asp-Gly (AEDG)\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 98% (batch-dependent; refer to Certificate of Analysis)\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e White to off-white lyophilized powder\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"yuansensetech","offers":[{"title":"ET 10mg","offer_id":52038356271394,"sku":"ET10","price":66.0,"currency_code":"USD","in_stock":true},{"title":"ET 50mg","offer_id":52038356304162,"sku":"ET50","price":194.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/Epithalon-10.jpg?v=1783741735","url":"https:\/\/yuansensepeptide.com\/products\/epithalon","provider":"Yuansensetech™","version":"1.0","type":"link"}