{"product_id":"igf-1lr3","title":"IGF-1LR3","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cdiv\u003eIGF-1 LR3 is a synthetic research peptide, an 83-amino acid polypeptide engineered as a lengthened analog of human IGF-1. IGF-1 LR3 peptide features an arginine substitution at position 3 and a 13-amino acid N-terminal extension, resulting in a markedly prolonged half-life of approximately 20–30 hours. This IGF-1 LR3 analog exhibits potent mitogenic and anabolic properties widely studied in cell growth, differentiation, and metabolic regulation research.\u003c\/div\u003e\n\u003cdiv\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eIGF-1 LR3 exerts its effects by binding to the Type 1 IGF receptor (IGF-1R), which is homologous to the insulin receptor. This receptor activation stimulates intracellular signaling cascades, primarily the PI3K\/AKT pathway and the MAPK\/ERK pathway (including ERK1\/2 signaling). These pathways promote cell proliferation, survival, differentiation, and metabolic processes including the uptake of glucose, fatty acids, and amino acids to support growing tissues. Unlike native IGF-1, IGF-1 LR3 has \u0026gt;100-fold reduced affinity for IGF-binding proteins (IGFBPs), which otherwise sequester native IGF-1 and limit its bioavailability. This structural advantage ensures sustained receptor engagement and enhanced biological potency—approximately three times more potent than native IGF-1.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCell Culture and Bioproduction:\u003c\/strong\u003e Widely used as a serum-free supplement in mammalian cell culture to promote cell growth, proliferation, and recombinant protein expression.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTissue Regeneration and Stem Cell Research:\u003c\/strong\u003e Investigated for stimulating proliferation and survival of various cell types including muscle, bone, and cartilage tissue.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Research:\u003c\/strong\u003e Employed to study glucose, fatty acid, and amino acid uptake, as well as insulin-like growth factor signaling pathways.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurobiology:\u003c\/strong\u003e Studied for neuroprotective effects, including amyloid plaque remodeling in the cerebral cortex.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSignal Transduction:\u003c\/strong\u003e Utilized to probe PI3K\/AKT and MAPK\/ERK pathways involved in metabolism, apoptosis, and gene expression.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 946870-92-4\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 9,117.5 g\/mol (9.1 kDa)\u003cbr\u003e\u003cstrong\u003eAmino Acids:\u003c\/strong\u003e 83 amino acids\u003cbr\u003e\u003cstrong\u003eSequence (One-Letter Code):\u003c\/strong\u003e MFPAMPLLSLFVNGPRTLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRELMYCAPLKPAKSA\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 95%–98% (batch-dependent; refer to Certificate of Analysis)\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e White to off-white lyophilized powder\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water (≥0.1 mg\/mL); prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"yuansensetech","offers":[{"title":"IG 0.1mg","offer_id":52038355845410,"sku":"IG01","price":45.0,"currency_code":"USD","in_stock":true},{"title":"IG 1mg","offer_id":52038355878178,"sku":"IG1","price":252.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/IGF-1LR3_1.jpg?v=1783743920","url":"https:\/\/yuansensepeptide.com\/products\/igf-1lr3","provider":"Yuansensetech™","version":"1.0","type":"link"}