{"product_id":"kisspeptin-10","title":"KissPeptin-10","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\n\u003cdetails class=\"peptide-details\" open\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eKisspeptin-10 (KP-10; also known as Metastin 45-54) is a synthetic decapeptide corresponding to the C-terminal residues 112–121 of the KISS1 gene-encoded precursor protein (or residues 45–54 of metastin). It represents the minimal sequence of kisspeptin required for full activation of the kisspeptin receptor (KISS1R, previously known as GPR54 or AXOR12). The compound is a single, non-glycosylated polypeptide chain containing 10 amino acids and was first identified as the endogenous ligand for the orphan G protein-coupled receptor GPR54. Kisspeptin-10 has been extensively studied for its role in reproductive neuroendocrinology, particularly as a master regulator of the hypothalamic-pituitary-gonadal (HPG) axis through stimulation of gonadotropin-releasing hormone (GnRH) secretion. The compound is widely employed in research applications spanning reproductive biology, oncology, neuroendocrinology, and metabolic disorders.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eKisspeptin-10 exerts its effects by selectively binding to and activating the kisspeptin receptor KISS1R (GPR54), a class A G protein-coupled receptor (GPCR). Upon receptor activation, kisspeptin-10 triggers intracellular signaling cascades, including the activation of phospholipase C (PLC), mobilization of intracellular calcium, and phosphorylation of extracellular signal-regulated kinases (ERK1\/2). The compound demonstrates high affinity for both rat and human KISS1 receptors, with Ki values of 1.59 nM and 2.33 nM, respectively. Activation of KISS1R in hypothalamic GnRH neurons stimulates the pulsatile secretion of GnRH, which in turn drives the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary. Beyond its canonical role in reproductive endocrinology, kisspeptin-10 has been shown to inhibit tumor metastasis and invasion, suppress angiogenesis through inhibition of VEGF expression and FAK\/Rho GTPase activation, promote osteoblast differentiation via GPR54-mediated regulation of BMP2 expression, and exert neuroprotective effects.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eReproductive Neuroendocrinology:\u003c\/strong\u003e Investigated as a master regulator of the HPG axis for studying GnRH secretion, LH\/FSH release, puberty onset, and fertility regulation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOncology and Metastasis Research:\u003c\/strong\u003e Employed to study tumor suppression mechanisms, inhibition of metastasis and invasion, and anti-angiogenic effects through suppression of VEGF expression.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBone and Osteoblast Differentiation:\u003c\/strong\u003e Studied for promoting osteogenic differentiation through GPR54-mediated NFATc4\/BMP2 signaling, with applications in bone formation and regeneration research.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection:\u003c\/strong\u003e Investigated for neurovascular protective effects following cerebral ischemia and preservation of blood-brain barrier integrity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic and Endocrine Disorders:\u003c\/strong\u003e Explored for therapeutic potential in gestational diabetes mellitus, polycystic ovary syndrome (PCOS), and infertility.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRadiopharmaceutical Development:\u003c\/strong\u003e Utilized as a targeting vector for gallium-68\/lutetium-177 labelled pan-tumour radiopharmaceuticals for cancer detection and therapy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 374675-21-5 (human)\u003cbr\u003e\n\u003cstrong\u003ePubChem CID:\u003c\/strong\u003e 25240297\u003cbr\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₆₃H₈₃N₁₇O₁₄\u003cbr\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 1,302.4–1,302.5 g\/mol\u003cbr\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ (YNWNSFGLRF-NH₂)\u003cbr\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99%\u003cbr\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water (up to 1 mg\/ml) and DMSO; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n","brand":"yuansensetech","offers":[{"title":"KS 5mg","offer_id":52038352503074,"sku":"KS5","price":80.0,"currency_code":"USD","in_stock":true},{"title":"KS 10mg","offer_id":52038352535842,"sku":"KS10","price":144.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/5.jpg?v=1783741662","url":"https:\/\/yuansensepeptide.com\/products\/kisspeptin-10","provider":"Yuansensetech™","version":"1.0","type":"link"}