{"product_id":"ll37","title":"LL37","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\u003cdetails open=\"\" class=\"peptide-details\"\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cspan\u003eLL37 is a synthetic research peptide, a 37-residue amphipathic cationic antimicrobial peptide belonging to the cathelicidin family. \u003c\/span\u003e It is the only cathelicidin-type peptide found in humans, corresponding to amino acids 134-170 of the human cationic antimicrobial protein 18 (hCAP18). LL-37 plays a key role in the first line of defense against local infection and systemic invasion of pathogens at sites of inflammation and wounds. The peptide exhibits a broad spectrum of antimicrobial activity against bacteria, fungi, and viruses, and is widely studied for its additional roles in immunomodulation, wound healing, and cancer research.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eLL-37 exerts its effects through multiple interconnected mechanisms. The primary antimicrobial mechanism involves disruption of microbial cell membranes through electrostatic interactions and pore formation. The peptide's cationic and α-helical structure allows it to interact with negatively charged microbial membranes, leading to membrane permeabilization, cell wall destruction, oxidative stress, and biofilm suppression. Beyond its direct antimicrobial effects, LL-37 modulates innate immunity through binding and inactivation of bacterial endotoxins and promoting chemotaxis of immune cells. It also exerts anti-inflammatory effects, chemo-attraction, and promotes wound healing and closure at infected sites.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntimicrobial Research:\u003c\/strong\u003e Investigated for its broad-spectrum activity against over 38 bacteria, 16 fungi, and 16 viruses, including antibiotic-resistant strains.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunomodulation:\u003c\/strong\u003e Employed to study innate immune responses, chemotaxis, LPS neutralization, and inflammatory response modulation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWound Healing:\u003c\/strong\u003e Studied for promoting wound healing, protecting cornea from infection, and regulating tissue repair processes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCancer Research:\u003c\/strong\u003e Investigated for its anticancer effects and role in cancer immunity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBiofilm Studies:\u003c\/strong\u003e Utilized as a validated positive control for biofilm prevention and inhibition studies.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 154947-66-7\u003cbr\u003e\u003cstrong\u003ePubChem CID:\u003c\/strong\u003e 137699680\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₂₀₅H₃₄₀N₆₀O₅₃\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 4,493.26 g\/mol\u003cbr\u003e\u003cstrong\u003eSequence:\u003c\/strong\u003e Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser (LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES)\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99%\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e","brand":"yuansensetech","offers":[{"title":"LL37  5mg","offer_id":52203079663906,"sku":"LL375","price":108.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/LL37.jpg?v=1783741677","url":"https:\/\/yuansensepeptide.com\/products\/ll37","provider":"Yuansensetech™","version":"1.0","type":"link"}