{"product_id":"lysine-proline-valine","title":"LYSINE-PROLINE-VALINE","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\u003cdetails open=\"\" class=\"peptide-details\"\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eKPV (Lysine-Proline-Valine) is a synthetic tripeptide corresponding to the C-terminal fragment (amino acids 11-13) of alpha-melanocyte-stimulating hormone (α-MSH). As a minimal bioactive motif of the melanocortin family, KPV has garnered significant research interest for its distinct anti-inflammatory and immunomodulatory properties, independent of the pigmentary effects associated with full-length α-MSH.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eUnlike full-length α-MSH, which signals through melanocortin receptors (MCRs), KPV exerts its anti-inflammatory effects through a non-classical, receptor-independent mechanism. Research indicates that KPV acts primarily through the inhibition of interleukin-1β (IL-1β) functions. A key molecular pathway involves the suppression of nuclear factor kappa-B (NF-κB) signaling. Specifically, KPV has been shown to inhibit the nuclear import of the p65 subunit of NF-κB, thereby blocking the transcription of pro-inflammatory genes. This results in the reduced production and release of multiple pro-inflammatory cytokines.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eInflammation Research:\u003c\/strong\u003e Widely utilized as a research tool to dissect the molecular mechanisms of inflammation and to study the inhibition of pro-inflammatory cytokine production and NF-κB activity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInflammatory Bowel Disease (IBD):\u003c\/strong\u003e Investigated in preclinical models for its potential to ameliorate intestinal inflammation, protect mucosal barrier function, and reduce tissue damage.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDermatology and Wound Healing:\u003c\/strong\u003e Studied for its capacity to accelerate wound healing, reduce infection, and modulate inflammation in skin barrier recovery models.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunomodulation:\u003c\/strong\u003e Employed in research exploring the regulation of immune cell activity, including macrophage polarization and T-cell modulation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 67727-97-3\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₁₆H₃₀N₄O₄\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 342.43 g\/mol\u003cbr\u003e\u003cstrong\u003eSequence (Three-Letter Code):\u003c\/strong\u003e H-Lys-Pro-Val-OH\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99% \u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e White to off-white lyophilized powder\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"yuansensetech","offers":[{"title":"KPV 5mg","offer_id":52038354075938,"sku":"KPV5","price":57.0,"currency_code":"USD","in_stock":true},{"title":"KPV 10mg","offer_id":52038354108706,"sku":"KPV10","price":77.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/LYSINE-PROLINE-VALINE.jpg?v=1783741704","url":"https:\/\/yuansensepeptide.com\/products\/lysine-proline-valine","provider":"Yuansensetech™","version":"1.0","type":"link"}