{"product_id":"mazdutide","title":"Mazdutide","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\n\u003cdetails class=\"peptide-details\" open\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eMazdutide (IBI-362; LY-3305677; OXM-3) is a long-acting synthetic analogue of the mammalian gut hormone oxyntomodulin. It functions as a dual agonist of the glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR), representing a novel therapeutic approach that combines the complementary metabolic benefits of both receptor pathways. The peptide structure incorporates a fatty-acyl moiety that extends its in vivo half-life. Mazdutide was developed through a collaboration between Innovent Biologics and Eli Lilly and received approval in China in 2025 for the treatment of type 2 diabetes and obesity.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eMazdutide exerts its effects through simultaneous activation of two complementary receptor pathways. Activation of the GLP-1 receptor (GLP-1R) promotes glucose-dependent insulin secretion, suppresses glucagon secretion, delays gastric emptying, and reduces appetite through central nervous system pathways. Activation of the glucagon receptor (GCGR) increases energy expenditure, promotes hepatic fat breakdown, and enhances fatty acid β-oxidation. This dual agonism not only provides synergistic weight reduction effects but also directly improves hepatic fat metabolism. Mazdutide binds human GCGR (Ki = 17.7 nM) and GLP-1R (Ki = 28.6 nM), and stimulates insulin secretion from mouse pancreatic islets (EC₅₀ = 5.2 nM).\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eObesity and Weight Management:\u003c\/strong\u003e Investigated for significant and sustained weight reduction. In Phase 2 obesity trials, mazdutide (9 mg) demonstrated clinically meaningful weight loss in Chinese adults with moderate to severe obesity. Dose-dependent reductions in body weight have been consistently observed.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eType 2 Diabetes Mellitus:\u003c\/strong\u003e Studied for glycemic control with substantial improvements in HbA1c. At week 24, mazdutide significantly reduced HbA1c versus placebo: −1.57% with 4 mg and −2.15% with 6 mg, versus −0.14% with placebo. The compound has demonstrated superior efficacy compared to dulaglutide in patients with type 2 diabetes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and NAFLD:\u003c\/strong\u003e Investigated for reducing hepatic fat content and improving liver fat metabolism through GCGR-mediated mechanisms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiometabolic Outcomes:\u003c\/strong\u003e Evaluated for effects on coronary plaque progression in patients with coronary atherosclerosis and overweight or obesity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eObstructive Sleep Apnea:\u003c\/strong\u003e Investigated in Phase 3 clinical trials for patients with moderate-to-severe OSA and BMI ≥ 28 kg\/m².\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 2259884-03-0\u003cbr\u003e\n\u003cstrong\u003ePubChem CID:\u003c\/strong\u003e 167312357 (also reported as 497620638 for SID)\u003cbr\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₂₁₀H₃₂₂N₄₆O₆₇\u003cbr\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 4,563.06 g\/mol\u003cbr\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e H-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-Lys-{AEEA-AEEA-γGlu-Nonadecanoic acid}-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH₂\u003cbr\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99%\u003cbr\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n","brand":"yuansensetech","offers":[{"title":"MDT 5mg","offer_id":52203347640610,"sku":"MDT5","price":150.0,"currency_code":"USD","in_stock":true},{"title":"MDT 10mg","offer_id":52203347673378,"sku":"MDT10","price":150.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/5mg_39fde926-afee-47b4-8d19-ad56e65841a4.jpg?v=1783741643","url":"https:\/\/yuansensepeptide.com\/products\/mazdutide","provider":"Yuansensetech™","version":"1.0","type":"link"}