{"product_id":"mt-2","title":"MT-2","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\u003cdetails open=\"\" class=\"peptide-details\"\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cdiv\u003eMelanotan-II(MT-II, MT-2) is a synthetic research peptide, a cyclic heptapeptide analogue of the endogenous α-melanocyte-stimulating hormone (α-MSH). Melanotan-II peptide acts as a powerful non-selective agonist of melanocortin receptors (MC1R, MC3R, MC4R, MC5R), widely studied for pigmentation, energy balance, sexual function, and neuroprotection. This Mt-2 analogue was developed in 1989 as a more potent and stable melanocortin ligand for research applications.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eMT-2 functions as a synthetic agonist of melanocortin receptors. Its primary effect on skin pigmentation is mediated through activation of the melanocortin 1 receptor (MC1R) on melanocytes. Upon binding to the G-protein-coupled MC1R, MT-2 activates adenylyl cyclase, which catalyzes the conversion of ATP to cyclic adenosine monophosphate (cAMP). The resulting increase in intracellular cAMP activates Protein Kinase A (PKA), which then phosphorylates the cAMP response element-binding protein (CREB). Phosphorylated CREB translocates to the nucleus and initiates transcription of the Microphthalmia-associated transcription factor (MITF) gene—the master regulator of melanocyte development and function. MITF subsequently activates key melanogenic enzymes, including tyrosinase, tyrosinase-related protein 1 (TRP-1), and TRP-2. Beyond MC1R, MT-2's activation of MC3R and MC4R contributes to its effects on energy balance, appetite suppression, and sexual function.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003ePigmentation and Photoprotection:\u003c\/strong\u003e Investigated for its ability to induce melanogenesis (eumelanin production), with potential applications in photoprotection and dermatological disorders.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic and Obesity Research:\u003c\/strong\u003e Employed in preclinical models to study appetite suppression, food intake reduction, and thermogenic responses.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSexual Function and Erectile Dysfunction:\u003c\/strong\u003e Studied for its dose-dependent induction of penile erection and reduction of latency to first erectile event. Its metabolite PT-141 (Bremelanotide) was subsequently developed for this indication.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection and Nerve Regeneration:\u003c\/strong\u003e Investigated for neuroprotective qualities and promotion of peripheral nerve regeneration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroendocrinology and Behavior:\u003c\/strong\u003e Utilized as a pharmacological tool to study melanocortin receptor signaling, social behavior, and stress responses.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 121062-08-6\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₅₀H₆₉N₁₅O₉\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 1,024.15–1,024.18 g\/mol\u003cbr\u003e\u003cstrong\u003eSequence:\u003c\/strong\u003e Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ (lactam bridge: Asp²–Lys⁷)\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99% (batch-dependent; refer to Certificate of Analysis)\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e White to off-white lyophilized powder\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Lyophilized powder stable at ≤ -20°C, desiccated, and protected from light. Upon reconstitution, store at 2–4°C for up to 7 days; for long-term storage, keep below -18°C and avoid repeated freeze-thaw cycles.\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water (≥5 mg\/mL) and DMSO; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"yuansensetech","offers":[{"title":"ML 10mg","offer_id":52038355648802,"sku":"ML10","price":60.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/MT-2.jpg?v=1783741723","url":"https:\/\/yuansensepeptide.com\/products\/mt-2","provider":"Yuansensetech™","version":"1.0","type":"link"}