{"product_id":"pinealon","title":"Pinealon","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\n\u003cdetails class=\"peptide-details\" open\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003ePinealon (also known as EDR peptide) is a synthetic tripeptide with the amino acid sequence Glu-Asp-Arg (EDR). It was developed by Russian scientist Vladimir Khavinson as part of a family of short peptide \"bioregulators\" and is documented in the Russian scientific literature as a geroprotector. Pinealon is a pineal gland-derived peptide bioregulator that has been extensively studied for its neuroprotective, cognitive-enhancing, and geroprotective properties. The small peptide nature of Pinealon gives it exceptional nuclear membrane permeability, enabling direct genomic interactions.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003ePinealon exerts its neuroprotective effects through multiple interconnected mechanisms. The peptide prevents the accumulation of reactive oxygen species (ROS) and suppresses the activation of ERK 1\/2 signaling pathways. It enhances the functional activity of major cellular components of brain tissue while reducing spontaneous cell death. Pinealon increases cell viability by suppressing free radical levels and activating proliferative processes, maintaining cellular homeostasis through regulation of apoptosis and necrosis mechanisms. The peptide may also interact with methylated and unmethylated DNA sequences, affecting DNA repair and gene expression.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection and Cognitive Enhancement:\u003c\/strong\u003e Investigated for its neuroprotective effects, including inhibition of ROS accumulation and ERK 1\/2 activation in neuronal cells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAging and Geroprotection:\u003c\/strong\u003e Studied as a geroprotector for its potential to maintain cellular homeostasis and reduce age-related cellular dysfunction.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrenatal Neurodevelopmental Protection:\u003c\/strong\u003e Demonstrated protective effects against prenatal hyperhomocysteinemia in rat offspring, improving postnatal cognitive function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOccupational Health and Adaptation:\u003c\/strong\u003e Employed in research on biological age parameters and adaptive responses in occupational settings.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDNA Interaction and Gene Expression:\u003c\/strong\u003e Utilized as a research tool to study peptide-DNA interactions and epigenetic regulation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 175175-23-2 (free base); 2703745-42-8 (acetate salt)\u003cbr\u003e\n\u003cstrong\u003ePubChem CID:\u003c\/strong\u003e 10273502\u003cbr\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₁₅H₂₆N₆O₈\u003cbr\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 418.41 g\/mol\u003cbr\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Glu-Asp-Arg (EDR); H-Glu-Asp-Arg-OH\u003cbr\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99%\u003cbr\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n","brand":"yuansensetech","offers":[{"title":"PI 5mg","offer_id":52038352961826,"sku":"PI5","price":60.0,"currency_code":"USD","in_stock":true},{"title":"PI 10mg","offer_id":52038352994594,"sku":"PI10","price":80.0,"currency_code":"USD","in_stock":true},{"title":"PI 20mg","offer_id":52038353027362,"sku":"PI20","price":120.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/5mg_cbd6d4eb-0b48-4595-a983-6e627b0e1fcf.jpg?v=1783741674","url":"https:\/\/yuansensepeptide.com\/products\/pinealon","provider":"Yuansensetech™","version":"1.0","type":"link"}