{"product_id":"pnc-27","title":"PNC 27","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\n\u003cdetails class=\"peptide-details\" open\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003ePNC-27 is a synthetic 32-residue chimeric anticancer peptide composed of an HDM-2 binding domain corresponding to residues 12–26 of the p53 protein and a cell-penetrating peptide (CPP) leader sequence. The compound belongs to a class of peptides designed to selectively target cancer cells while sparing normal, untransformed cells. PNC-27 has demonstrated potent antitumor activity against a wide range of cancer cell lines, including acute myeloid leukemia, cervical squamous cancer, ovarian cancer, colon cancer, and pancreatic carcinoma.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003ePNC-27 exerts its selective anticancer effects through a unique dual-targeting mechanism. The peptide binds to the p53 binding site of HDM-2 (residues 1–109), a protein that is uniquely expressed on the plasma membranes of cancer cells but not on normal cells. Following binding, PNC-27 induces the formation of transmembrane pores, resulting in the extrusion of intracellular contents and cancer cell necrosis. Additionally, PNC-27 enters cancer cells and binds to mitochondrial membranes, causing mitochondrial disruption. The peptide exhibits selective cytotoxicity across a broad range of cancer types while demonstrating no effect on normal cells.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAcute Myeloid Leukemia:\u003c\/strong\u003e Investigated for its potent anti-leukemic activity, with in vivo studies demonstrating efficacy via intraperitoneal administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOvarian Cancer:\u003c\/strong\u003e Studied for efficacy against both treatment-naïve and chemotherapy-resistant ovarian cancer cell lines, with demonstrated synergism when combined with paclitaxel.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCervical Cancer:\u003c\/strong\u003e Employed in research on squamous cervical cancer, with selective killing of cancer cells while sparing normal cervical cells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eColon Cancer:\u003c\/strong\u003e Investigated for selective killing of colon cancer stem cells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCombination Therapy Studies:\u003c\/strong\u003e Explored in combination with conventional chemotherapeutic agents to overcome drug resistance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 1159861-00-3\u003cbr\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₁₈₈H₂₉₃N₅₃O₄₄S\u003cbr\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 4,031.73 g\/mol\u003cbr\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e H-Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly-OH\u003cbr\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99%\u003cbr\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n","brand":"yuansensetech","offers":[{"title":"PNC 5mg","offer_id":52038352863522,"sku":"PNC5","price":130.0,"currency_code":"USD","in_stock":true},{"title":"PNC 10mg","offer_id":52038352896290,"sku":"PNC10","price":230.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/PNC27.jpg?v=1783741671","url":"https:\/\/yuansensepeptide.com\/products\/pnc-27","provider":"Yuansensetech™","version":"1.0","type":"link"}