{"product_id":"reta","title":"Reta","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\u003cdetails class=\"peptide-details\" open=\"\"\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eReta\/Retatrutide (LY3437943) is a first-in-class, single-molecule, triple hormone receptor agonist developed by Eli Lilly. It is a 39-amino acid synthetic peptide engineered to simultaneously activate the glucose-dependent insulinotropic polypeptide receptor (GIPR), the glucagon-like peptide-1 receptor (GLP-1R), and the glucagon receptor (GCGR). This triple-agonist design represents a novel therapeutic approach that builds upon the dual-agonist platform of tirzepatide (GIP\/GLP-1) by incorporating glucagon receptor activation to enhance energy expenditure. The compound is currently in Phase 3 clinical trials for obesity, type 2 diabetes, and related comorbidities, with a New Drug Application (NDA) submission expected in late 2026 or early 2027.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eRetatrutide exerts its effects through simultaneous activation of three key metabolic hormone receptors. GIPR agonism enhances glucose-dependent insulin secretion from pancreatic beta cells. GLP-1R agonism improves glycemic control by enhancing insulin secretion, suppressing glucagon secretion, slowing gastric emptying, and promoting satiety. GCGR agonism increases energy expenditure, contributing to greater body weight losses compared to GLP-1-based therapies.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eObesity and Weight Management:\u003c\/strong\u003e Investigated for significant and sustained weight reduction. In a Phase 2 obesity trial, retatrutide demonstrated an average weight loss of 24.2% at 48 weeks in the 12 mg dose group. Phase 3 TRIUMPH-1 results have shown unprecedented weight loss approaching levels comparable to bariatric surgery.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eType 2 Diabetes Mellitus:\u003c\/strong\u003e Studied for glycemic control with substantial improvements in HbA1c. In Phase 2 trials, retatrutide achieved an HbA1c reduction of 2.2%, with 82% of participants reaching glycemic targets. Phase 3 TRANSCEND-T2D-1 results were announced in 2026.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiometabolic Diseases:\u003c\/strong\u003e Investigated for cardiovascular and renal outcomes, metabolic dysfunction-associated steatotic liver disease (MASLD), and non-alcoholic fatty liver disease.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEmerging Applications:\u003c\/strong\u003e Studied for knee osteoarthritis pain, moderate-to-severe obstructive sleep apnea (OSA), and chronic low back pain.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 2381089-83-2\u003cbr\u003e\u003cstrong\u003ePubChem SID:\u003c\/strong\u003e 497620843\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₂₂₁H₃₄₂N₄₆O₆₈\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 4,731.34 g\/mol\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 98% (batch-dependent; refer to Certificate of Analysis)\u003cbr\u003e\u003cstrong\u003eSequence:\u003c\/strong\u003e Tyr-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{α-Me-Leu}-Leu-Asp-Lys-{diacid-C20-gamma-Glu-(AEEA)-Lys}-Ala-Gln-{Aib}-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"yuansensetech","offers":[{"title":"RT 5mg","offer_id":52038355190050,"sku":"RT5","price":72.0,"currency_code":"USD","in_stock":true},{"title":"RT 10mg","offer_id":52038355222818,"sku":"RT10","price":117.0,"currency_code":"USD","in_stock":true},{"title":"RT 15mg","offer_id":52038355255586,"sku":"RT15","price":143.0,"currency_code":"USD","in_stock":true},{"title":"RT 20mg","offer_id":52038355288354,"sku":"RT20","price":175.0,"currency_code":"USD","in_stock":true},{"title":"RT 30mg","offer_id":52038355353890,"sku":"RT30","price":215.0,"currency_code":"USD","in_stock":true},{"title":"RT 40mg","offer_id":52038355419426,"sku":"RT40","price":267.0,"currency_code":"USD","in_stock":true},{"title":"RT 50mg","offer_id":52038355452194,"sku":"RT50","price":310.0,"currency_code":"USD","in_stock":true},{"title":"RT 60mg","offer_id":52038355484962,"sku":"RT60","price":354.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/Reta_92d06580-0603-4e9f-b79f-6d073d3daa5d.jpg?v=1783741719","url":"https:\/\/yuansensepeptide.com\/products\/reta","provider":"Yuansensetech™","version":"1.0","type":"link"}