{"product_id":"semax","title":"Semax","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\u003cdetails class=\"peptide-details\" open=\"\"\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eSemex is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the adrenocorticotropic hormone ACTH(4-10) fragment. It was developed in Russia in the 1980s and 1990s as a derivative of ACTH, with the goal of creating a peptide that possessed neuroprotective and cognitive-enhancing properties without the endocrine side effects of the parent hormone. The synthetic peptide consists of the ACTH(4-7) core (Met-Glu-His-Phe), which retains the neurotropic activity of ACTH but lacks corticotropic activity, and a C-terminal Pro-Gly-Pro (PGP) extension that acts as a metabolic \"shield\" against peptidases, significantly extending its half-life in plasma and cerebrospinal fluid. The compound is classified as a nootropic and neuroprotective agent with demonstrated anxiolytic and antidepressant properties.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eSemex exerts its effects through multiple interconnected mechanisms. It acts as a modulator of the melanocortin system, potentially interacting with MC4R and MC5R receptors. A key mechanism is the rapid and potent upregulation of brain-derived neurotrophic factor (BDNF) and its high-affinity receptor TrkB. This upregulation is driven by intracellular signaling cascades, including the cAMP-PKA-CREB pathway, which promotes transcription of the Bdnf gene. Semex also regulates cortical nitric oxide (NO) production, sequesters copper ions, and interacts directly with Aβ:Cu²⁺ oligomers, leading to reduced amyloid β protein aggregation.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eIschemic Stroke and Neuroprotection:\u003c\/strong\u003e Investigated for its pronounced neuroprotective effects in the treatment of cerebrovascular insufficiency and acute cerebral stroke.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCognitive Enhancement and Nootropic Studies:\u003c\/strong\u003e Employed in research to evaluate its positive influence on memory, learning, attention, and cognitive function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnxiety and Mood Research:\u003c\/strong\u003e Studied for its anxiolytic and antidepressant effects, with demonstrated ability to reduce anxiety-like behavior and normalize levels of brain biogenic amines.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurodegenerative Disease Models:\u003c\/strong\u003e Used in preclinical models to investigate its potential to reduce amyloid β aggregation and fibrillogenesis, with relevance to Alzheimer's disease research.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 80714-61-0 (free base); 2828433-33-4 (acetate salt)\u003cbr\u003e\u003cstrong\u003ePubChem CID:\u003c\/strong\u003e 9811102\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₃₇H₅₁N₉O₁₀S\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 813.92 g\/mol\u003cbr\u003e\u003cstrong\u003eSequence:\u003c\/strong\u003e Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 98% (batch-dependent; refer to Certificate of Analysis)\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e White to off-white lyophilized powder\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water, PBS (pH 7.2), and DMSO; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"yuansensetech","offers":[{"title":"XA 5mg","offer_id":52038354862370,"sku":"XA5","price":52.0,"currency_code":"USD","in_stock":true},{"title":"XA 10mg","offer_id":52038354895138,"sku":"XA10","price":67.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/Semax.jpg?v=1783741715","url":"https:\/\/yuansensepeptide.com\/products\/semax","provider":"Yuansensetech™","version":"1.0","type":"link"}