{"product_id":"snap-8","title":"Snap-8","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\u003cdetails class=\"peptide-details\" open=\"\"\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eSnap-8 (Acetyl Octapeptide-3, also known as Acetyl Glutamyl Heptapeptide-3) is a synthetic octapeptide developed as an advanced analogue of Argireline® (Acetyl Hexapeptide-8). It consists of an 8-amino-acid sequence that mimics the N-terminal end of the SNAP-25 protein, a critical component of the SNARE complex involved in neurotransmitter release. Originally developed by Spanish company Lipotec, Snap-8 is classified as a non-invasive peptide for modulating muscle contraction and is widely studied for its applications in topical formulations.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eSnap-8 exerts its effects through competitive inhibition of SNARE complex formation. The peptide mimics the N-terminal domain of SNAP-25 and competes with the native protein for binding to syntaxin and synaptobrevin, occupying sites normally reserved for SNAP-25 within the SNARE complex. This competitive binding sterically hinders the assembly of a functional SNARE complex, thereby modulating neurotransmitter release without permanently blocking it. Unlike botulinum toxin, which cleaves SNAP-25 and causes muscle paralysis, Snap-8 acts through reversible competitive binding, resulting in muscle relaxation rather than paralysis. This interaction attenuates the release of acetylcholine at the neuromuscular junction, reducing the muscle contractions that lead to the formation of expression-related dynamic wrinkles.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCosmetic and Topical Formulations:\u003c\/strong\u003e Investigated as a non-invasive alternative to botulinum toxin for reducing expression-related dynamic wrinkles in topical creams, serums, and microneedle patches.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuromodulation and Neurotransmitter Research:\u003c\/strong\u003e Employed as a molecular probe for studying regulated exocytosis, neurotransmitter release analogue systems, and intracellular trafficking pathways.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProtein-Protein Interaction Studies:\u003c\/strong\u003e Utilized as a tool for probing cellular signaling pathways through interference with SNARE-mediated protein-protein interactions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eComparative Efficacy Studies:\u003c\/strong\u003e Used in research evaluating anti-wrinkle efficacy, with studies demonstrating a 34.98% wrinkle depth reduction vs. 27.05% for Argireline in 28-day trials, and ~30% greater activity compared to acetyl hexapeptide-8.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\" open=\"\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 868844-74-0\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₄₁H₇₀N₁₆O₁₆S\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 1,075.16 g\/mol\u003cbr\u003e\u003cstrong\u003eSequence:\u003c\/strong\u003e Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂ (Ac-EEMQRRAD-NH₂)\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99%\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e","brand":"yuansensetech","offers":[{"title":"NP8 10mg","offer_id":52038354010402,"sku":"NP810","price":56.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/Snap-8.jpg?v=1783741701","url":"https:\/\/yuansensepeptide.com\/products\/snap-8","provider":"Yuansensetech™","version":"1.0","type":"link"}