{"product_id":"ss-31","title":"SS-31","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\u003cdetails open=\"\" class=\"peptide-details\"\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eSS-31 is a synthetic research peptide with the sequence D-Arg-Dmt-Lys-Phe-NH₂ from the Szeto-Schiller family of mitochondria-targeting compounds. SS-31 peptide was discovered by Dr. Hazel Szeto at Weill Cornell Medical College and is designed to address mitochondrial dysfunction across cardiovascular, neurodegenerative, metabolic, and muscle-related research. This SS-31 tetrapeptide has garnered significant interest for its therapeutic potential in conditions including cardiovascular disease, neurodegeneration, and metabolic syndrome.\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eSS-31 exerts its effects through highly selective targeting of the inner mitochondrial membrane. It selectively binds to cardiolipin (CL), a unique phospholipid found almost exclusively in the inner mitochondrial membrane. This binding stabilizes mitochondrial cristae structure, reduces oxidative stress, and enhances adenosine triphosphate (ATP) production. SS-31 also inhibits the peroxidase activity of cytochrome c (cytc), enhancing electron transfer while reducing electron leakage, and prevents the opening of the mitochondrial permeability transition pore that forms under mitochondrial stress. Through these mechanisms, SS-31 improves mitochondrial bioenergetics, minimizes oxidative stress, and restores mitochondrial function in energy-depleted cells.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiovascular Research:\u003c\/strong\u003e Investigated for protective effects in heart failure, ischemia-reperfusion injury, and myocardial infarction. Clinical trials such as PROGRESS-HF have evaluated its efficacy in heart failure patients.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitochondrial Myopathy:\u003c\/strong\u003e Studied in primary mitochondrial myopathy through the MMPOWER-3 Phase 3 clinical trial.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurodegenerative Diseases:\u003c\/strong\u003e Employed in preclinical models to evaluate neuroprotective effects in traumatic brain injury, stroke, Alzheimer's disease, and Parkinson's disease.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRare Genetic Disorders:\u003c\/strong\u003e Investigated for Barth syndrome (BTHS), with FDA Rare Pediatric Disease designation, and Friedreich's ataxia.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAge-Related Conditions:\u003c\/strong\u003e Studied for dry age-related macular degeneration and improving mitochondrial function in aged oocytes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 736992-21-5 (free base); 1334953-95-5 (acetate salt)\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₃₂H₄₉N₉O₅\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 639.79 g\/mol\u003cbr\u003e\u003cstrong\u003eSequence:\u003c\/strong\u003e D-Arg-Dmt-Lys-Phe-NH₂ (Dmt = 2,6-dimethyl-L-tyrosine)\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 98% (batch-dependent; refer to Certificate of Analysis)\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water, PBS (pH 7.2), and DMSO; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e","brand":"yuansensetech","offers":[{"title":"SS 10mg","offer_id":52038354731298,"sku":"2S10","price":139.0,"currency_code":"USD","in_stock":true},{"title":"SS 50mg","offer_id":52038354764066,"sku":"2S50","price":420.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/SS-31.jpg?v=1783741712","url":"https:\/\/yuansensepeptide.com\/products\/ss-31","provider":"Yuansensetech™","version":"1.0","type":"link"}