{"product_id":"thymalin","title":"Thymalin","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\n\u003cdetails class=\"peptide-details\" open\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eThymalin is a polypeptide complex isolated from the thymus gland of calves, developed by the St. Petersburg Institute of Bioregulation and Gerontology. It is a peptide-based bioregulator that has been extensively studied for its immunomodulatory, geroprotective, and regenerative properties. Thymalin is often used interchangeably with Thymulin (also known as Serum Thymic Factor or Nonathymulin), a synthetic nonapeptide (Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH) that represents the active component of the thymic polypeptide complex. The compound has been approved as a medicinal drug in Russia (registration number LS-000267) since 2010 and has demonstrated efficacy in various infectious diseases, immunodeficiencies, and as an adjunct in cancer therapy.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eThymalin exerts its immunomodulatory effects through the actions of its active short peptide components—the dipeptides KE, EW, and the tripeptide EDP. These short peptides can specifically bind to double-stranded DNA and\/or histone proteins, regulating gene expression and the synthesis of immune system proteins. This epigenetic regulatory mechanism influences the differentiation, proliferation, and apoptosis of immune cells. Thymalin enhances functional activity of T lymphocytes, stimulates cellular immunity, activates macrophages, and increases phagocytosis. It has been shown to reduce the synthesis of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in human peripheral blood mononuclear cells, while normalizing the number and ratio of T and B lymphocytes and their subpopulations.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunodeficiency and Immunomodulation:\u003c\/strong\u003e Investigated for the treatment of primary and secondary immunodeficiencies, immune dysfunction-related diseases, and restoration of immune balance in immunocompromised states.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAging and Geroprotection:\u003c\/strong\u003e Studied for reversing age-related thymic atrophy, restoring T-cell output, and reducing mortality in elderly populations over long-term observation periods.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInfectious Disease Research:\u003c\/strong\u003e Employed in studies on acute and chronic viral infections, including hepatitis, influenza, COVID-19, and pneumonia. In severe COVID-19 patients, Thymalin demonstrated reduced hospital mortality and faster clinical improvement.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCancer Adjuvant Therapy:\u003c\/strong\u003e Investigated as an adjunct in comprehensive cancer treatment, modulating immune responses against cancer cells and mitigating bone marrow suppression from chemo- or radiotherapy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInflammatory and Autoimmune Conditions:\u003c\/strong\u003e Studied for its anti-inflammatory effects and potential applications in conditions involving immune dysregulation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 63958-90-7 (Thymulin\/nonapeptide); 79621-14-0 (alternative)\u003cbr\u003e\n\u003cstrong\u003ePubChem CID:\u003c\/strong\u003e 3085284\u003cbr\u003e\n\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₃₃H₅₄N₁₂O₁₅\u003cbr\u003e\n\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 858.85–858.86 g\/mol\u003cbr\u003e\n\u003cstrong\u003eSequence:\u003c\/strong\u003e Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH\u003cbr\u003e\n\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99%\u003cbr\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\n\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n","brand":"yuansensetech","offers":[{"title":"TY 10mg","offer_id":52203059806498,"sku":"TY10","price":80.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/Thymalin.jpg?v=1783741678","url":"https:\/\/yuansensepeptide.com\/products\/thymalin","provider":"Yuansensetech™","version":"1.0","type":"link"}