{"product_id":"tirzepatide","title":"Tirzepatide","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\u003cdetails class=\"peptide-details\" open=\"\"\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cdiv\u003eTirzepatide is a research peptide, a first-in-class dual GIP and GLP-1 receptor agonist. Tirzepatide peptide is a 39-amino acid linear synthetic compound conjugated to a C20 fatty diacid moiety, enabling albumin binding and prolonged half-life for once-weekly dosing. This TIRZ dual-agonist formulation was FDA-approved in 2022 for type 2 diabetes management and is also studied for weight reduction and obstructive sleep apnea research.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eTirzepatide selectively binds to and activates both the GIP and GLP-1 receptors, the targets for native GIP and GLP-1. Receptor pharmacology studies reveal that tirzepatide is an imbalanced and biased dual agonist: it engages the GIP receptor (GIPR) to a greater degree than the GLP-1 receptor (GLP-1R), and displays biased signaling at the GLP-1R to favor cAMP generation over β-arrestin recruitment, coincident with a weaker ability to drive GLP-1R internalization compared with GLP-1. This unique pharmacological profile enhances insulin secretion (first- and second-phase) and reduces glucagon levels, both in a glucose-dependent manner. GIP also plays a role in nutrient and energy metabolism, while GLP-1 delays gastric emptying, suppresses appetite, and improves satiety.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eType 2 Diabetes Mellitus:\u003c\/strong\u003e Investigated as a therapeutic agent for glycemic control, demonstrating superior efficacy in lowering HbA1c compared with selective GLP-1 receptor agonists.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eObesity and Weight Management:\u003c\/strong\u003e Employed in preclinical and clinical studies to evaluate significant and sustained weight reduction, with effects approaching those achieved with bariatric surgery.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiometabolic Diseases:\u003c\/strong\u003e Studied for beneficial effects on heart failure with preserved ejection fraction, metabolic dysfunction–associated steatohepatitis (MASH), and cardiovascular outcomes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEmerging Applications:\u003c\/strong\u003e Investigated for potential benefits in chronic kidney disease, neurological disorders including Alzheimer's and Parkinson's diseases, and alcohol use disorder.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\" open=\"\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 2023788-19-2\u003cbr\u003e\u003cstrong\u003ePubChem CID:\u003c\/strong\u003e 156588324\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₂₂₅H₃₄₈N₄₈O₆₈\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 4,813.53 g\/mol\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99% (batch-dependent; please refer to the Certificate of Analysis)\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e White to off-white lyophilized powder\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in water and DMSO; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"yuansensetech","offers":[{"title":"TR 5mg","offer_id":52038354239778,"sku":"TR5","price":50.0,"currency_code":"USD","in_stock":true},{"title":"TR 10mg","offer_id":52038354272546,"sku":"TR10","price":67.0,"currency_code":"USD","in_stock":true},{"title":"TR 15mg","offer_id":52038354305314,"sku":"TR15","price":87.0,"currency_code":"USD","in_stock":true},{"title":"TR 20mg","offer_id":52038354338082,"sku":"TR20","price":106.0,"currency_code":"USD","in_stock":true},{"title":"TR 30mg","offer_id":52038354370850,"sku":"TR30","price":150.0,"currency_code":"USD","in_stock":true},{"title":"TR 40mg","offer_id":52038354403618,"sku":"TR40","price":182.0,"currency_code":"USD","in_stock":true},{"title":"TR 45mg","offer_id":52038354436386,"sku":"TR45","price":204.0,"currency_code":"USD","in_stock":true},{"title":"TR 50mg","offer_id":52038354469154,"sku":"TR50","price":217.0,"currency_code":"USD","in_stock":true},{"title":"TR 60mg","offer_id":52038354501922,"sku":"TR60","price":252.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/Tirz.jpg?v=1783741708","url":"https:\/\/yuansensepeptide.com\/products\/tirzepatide","provider":"Yuansensetech™","version":"1.0","type":"link"}