{"product_id":"vesugen","title":"Vesugen","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\u003cdetails open=\"\" class=\"peptide-details\"\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eVesugen (T-38) is a synthetic tripeptide with the sequence Lys-Glu-Asp (KED). It is one of a number of small peptide bioregulators developed in Russia in the late 1990s and early 2000s by the St. Petersburg Institute of Bioregulation and Gerontology. Its design is derived from a peptide complex isolated from the vascular tissue of young animals. The compound has been investigated for its purported vasoprotective, anti-aging, and regenerative properties, with a primary focus on microvascular network health.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eVesugen exerts its effects through multi-level cellular and molecular regulation. It is theorized to function through modulation rather than classical receptor activation. Key mechanisms include:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpigenetic Gene Regulation:\u003c\/strong\u003e Vesugen is hypothesized to interact directly with DNA, particularly binding to the promoter region of the MKI67 gene (encoding the proliferation marker Ki-67). This interaction may epigenetically regulate gene expression, promoting endothelial cell proliferation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVascular Endothelial Support:\u003c\/strong\u003e The compound promotes the proliferation and differentiation of vascular endothelial cells, which is crucial for vascular repair and maintaining vascular integrity. It has been shown to stimulate proliferation-associated proteins in vascular endothelial cell cultures.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRegulation of Gene Expression and Chromatin State:\u003c\/strong\u003e Vesugen can bind specifically to DNA, modulating chromatin conformation and gene transcriptional activity. This affects the synthesis of various proteins related to vascular function and may reduce the expression of inflammatory factors.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePromotion of Angiogenesis and Remodeling:\u003c\/strong\u003e In vitro experiments demonstrate protective effects on vascular cells, improving microcirculation and enhancing vascular elasticity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnhancement of Stress Resistance and Antioxidant Capacity:\u003c\/strong\u003e Vesugen can improve an organism's tolerance to stressful conditions like hypoxia and reduce oxidative damage to neural and vascular cells.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInfluence on Nitric Oxide (NO) Synthesis:\u003c\/strong\u003e Vesugen is thought to exert an influence on nitric oxide synthesis, a critical molecule in vascular integrity and blood flow regulation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eVascular and Endothelial Research:\u003c\/strong\u003e Investigated for its vasoprotective effects, including the promotion of endothelial cell proliferation, repair of microvessels, and improvement of blood flow. Studies have explored its potential role in vascular disease models, such as atherosclerosis and chronic arterial insufficiency.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAging and Geroprotective Studies:\u003c\/strong\u003e Employed in research on cellular aging, with studies suggesting it may support chromosomal integrity and promote proliferation in aged endothelial cell populations. Vesugen has demonstrated a more visible geroprotective effect than Pinealon in some studies.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCellular and Molecular Biology:\u003c\/strong\u003e Utilized as a research tool to study peptide-DNA interactions, epigenetic regulation of gene expression, and the modulation of cellular signaling pathways.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection:\u003c\/strong\u003e Investigated for its neurotropic effects in brain tissue, with potential applications in research on organic brain syndrome and central nervous system function.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\" open=\"\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 204271-66-9\u003cbr\u003e\u003cstrong\u003ePubChem CID:\u003c\/strong\u003e Not available in the reviewed sources\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₁₅H₂₆N₄O₈\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 390.39 g\/mol\u003cbr\u003e\u003cstrong\u003eSequence:\u003c\/strong\u003e Lys-Glu-Asp (KED)\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99%\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e","brand":"yuansensetech","offers":[{"title":"VE 20mg","offer_id":52209581523234,"sku":"VE20","price":150.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/20mg_2c1d828e-b809-4140-8cd6-ad06b122e59c.jpg?v=1783741641","url":"https:\/\/yuansensepeptide.com\/products\/vesugen","provider":"Yuansensetech™","version":"1.0","type":"link"}