{"product_id":"vilon","title":"Vilon","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\u003cdetails open=\"\" class=\"peptide-details\"\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eVilon (Lys-Glu) is a synthetic dipeptide bioregulator composed of the amino acids lysine and glutamic acid. It was developed by the St. Petersburg Institute of Bioregulation and Gerontology. As one of the shortest known peptides with significant biological activity, Vilon has garnered research interest for its potential role in supporting immune balance, cellular resilience, and healthy aging.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eVilon exerts its biological effects through several interconnected mechanisms, primarily at the genomic level:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eEpigenetic Regulation and Chromatin Remodeling:\u003c\/strong\u003e Vilon is hypothesized to interact directly with cellular chromatin. In aging cells, chromatin becomes excessively condensed (heterochromatinization), which can deactivate genes. Vilon may induce deheterochromatinization (unrolling\/decondensation) of specific chromosome regions, reactivating previously silenced genes, including ribosomal genes critical for protein synthesis. It selectively targets specific chromosomal regions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGene Expression Modulation:\u003c\/strong\u003e Research suggests Vilon may regulate the expression of key genes involved in cellular aging, immunity, and maintenance. In mesenchymal stem cell models, it has been shown to influence genes including IGF1, FOXO1, TERT (telomerase), TNKS2, and NFκB. It also modulates proteins associated with proliferation and extracellular matrix remodeling, such as Ki-67 and MMP-9.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunomodulation:\u003c\/strong\u003e Vilon acts as an immunomodulator, particularly influencing the thymus, the central organ of the immune system. It stimulates the differentiation of thymocyte precursors into mature CD5+ cells, which develop into T-helper cells and cytotoxic CD8+ T cells. It also produces a potent comitogenic effect on thymocyte proliferation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunology and Immune Support:\u003c\/strong\u003e Investigated for its immunomodulatory properties, including its influence on T-cell differentiation, thymocyte proliferation, and immune balance.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAging and Geroprotective Research:\u003c\/strong\u003e Studied for its potential geroprotective effects, which are believed to arise from its ability to remodel chromatin, reactivate genes in aging cells, and support cellular maintenance pathways.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGene Regulation and Epigenetics:\u003c\/strong\u003e Employed as a research tool to study peptide-DNA interactions, chromatin remodeling, and the modulation of gene expression.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOncology Research:\u003c\/strong\u003e Investigated for its oncostatic effects. In animal models of carcinogenesis, Vilon treatment was associated with a reduction in the incidence of induced tumors.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGastrointestinal and Metabolic Research:\u003c\/strong\u003e Studied for its ability to improve the transport characteristics of the small intestine in aged rats by increasing the activity of membrane enzymes.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\" open=\"\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 45234-02-4\u003cbr\u003e\u003cstrong\u003ePubChem CID:\u003c\/strong\u003e 7010502\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₁₁H₂₁N₃O₅\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 275.30 g\/mol\u003cbr\u003e\u003cstrong\u003eSequence:\u003c\/strong\u003e Lys-Glu (KE)\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99%\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e","brand":"yuansensetech","offers":[{"title":"VI 20mg","offer_id":52209584537890,"sku":"VI20","price":150.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/20mg_a122b790-04e8-4211-928e-8f2181251e5d.jpg?v=1783741640","url":"https:\/\/yuansensepeptide.com\/products\/vilon","provider":"Yuansensetech™","version":"1.0","type":"link"}