{"product_id":"vip","title":"VIP（Vasoactive Intestinal Peptide）","description":"\u003cstyle\u003e\n.peptide-details {\n  border: 1px solid #8A97B5;\n  margin-bottom: 8px;\n  border-radius: 8px;\n  overflow: hidden;\n}\n.peptide-details summary {\n  cursor: pointer;\n  padding: 12px 16px;\n  font-weight: bold;\n  list-style: none;\n  display: flex;\n  align-items: center;\n  justify-content: space-between;\n}\n.peptide-details summary::-webkit-details-marker {\n  display: none;\n}\n.peptide-details summary::after {\n  content: '';\n  display: inline-block;\n  width: 8px;\n  height: 8px;\n  border-right: 1px solid #8A97B5;\n  border-bottom: 1px solid #8A97B5;\n  transform: rotate(45deg);\n  transition: transform 0.2s ease;\n  flex-shrink: 0;\n  margin-left: 10px;\n}\n.peptide-details[open] summary::after {\n  transform: rotate(-135deg);\n}\n.peptide-details .peptide-content {\n  padding: 16px;\n}\n\u003c\/style\u003e\n\u003ch3 class=\"fusion-title-heading title-heading-left fusion-responsive-typography-calculated\"\u003eProduct Description\u003c\/h3\u003e\n\u003cdetails class=\"peptide-details\" open=\"\"\u003e\n\u003csummary\u003eOverview\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eVasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide belonging to the glucagon\/secretin superfamily, functioning as a ligand for class II G protein-coupled receptors. It is widely expressed in vertebrates, including the gastrointestinal tract, central nervous system, and endocrine organs, with roles in vasodilation, immune modulation, and metabolic regulation. VIP is a single, non-glycosylated polypeptide chain. The compound has a short plasma half-life (~2 minutes), limiting its therapeutic applications unless stabilized via chemical modifications.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eMechanism of Action\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003eVIP binds to the receptors VPAC1, VPAC2 and with less sensitivity to PAC1, which trigger a G-alpha-mediated signalling cascade, eventually activating adenyl cyclase leading to increases in cAMP and PKA. The PKA then activates other intracellular signaling pathways like the phosphorylation of CREB and other transcriptional factors. VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. It is an antiproliferative, anti-inflammatory and immune-regulatory peptide, acting by inhibiting phagocytic activity, free radical production, adherence and migration of macrophages.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eResearch Applications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eInflammation and Immunology:\u003c\/strong\u003e Investigated for its ability to downregulate proinflammatory cytokines (TNF-α, IL-6, IL-12) and upregulate anti-inflammatory IL-10. VIP has potent anti-inflammatory activity in animal models of respiratory distress, acute lung injury and inflammation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMetabolic Regulation:\u003c\/strong\u003e Studied for enhancing insulin sensitivity and glucose metabolism, offering adjunct benefits for patients on GLP-1 receptor agonist therapy. Preclinical data suggest VIP modulates glycogenolysis and lipid metabolism.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOsteoprotective Effects:\u003c\/strong\u003e Demonstrated osteoprotective effects by inhibiting osteoclastogenesis and promoting osteoblast differentiation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eChondrogenesis and Osteoarthritis:\u003c\/strong\u003e Investigated for promoting chondrogenic differentiation of human bone marrow mesenchymal stem cells, exerting anti-inflammatory and anti-catabolic effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeuroprotection and Neurotransmission:\u003c\/strong\u003e Studied for its role in neurotransmission and neurotrophism, as well as neuroprotective effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRespiratory and Pulmonary Research:\u003c\/strong\u003e VIP has been used in clinical trials for sarcoidosis, pulmonary fibrosis, asthma\/allergy, and pulmonary hypertension. It provides rapid respiratory failure reduction in clinically ill patients with COVID-19.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCancer Research:\u003c\/strong\u003e Identified as a potentially bioactive agent for cancer-related diseases.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"peptide-details\"\u003e\n\u003csummary\u003eProduct Specifications\u003c\/summary\u003e\n\u003cdiv class=\"peptide-content\"\u003e\n\u003cp\u003e\u003cstrong\u003eCAS Number:\u003c\/strong\u003e 40077-57-4\u003cbr\u003e\u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₁₄₇H₂₃₈N₄₄O₄₂S\u003cbr\u003e\u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 3,325.8 g\/mol\u003cbr\u003e\u003cstrong\u003eSequence:\u003c\/strong\u003e His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂\u003cbr\u003e\u003cstrong\u003ePurity:\u003c\/strong\u003e ≥ 99%\u003cbr\u003e\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilized powder\u003cbr\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at ≤ -20°C in a cool, dry place, protected from light and moisture\u003cbr\u003e\u003cstrong\u003eSolubility:\u003c\/strong\u003e Soluble in sterile water; prepare working solutions per laboratory protocol\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e","brand":"yuansensetech","offers":[{"title":"VIP 5mg","offer_id":52038353944866,"sku":"VIP5","price":108.0,"currency_code":"USD","in_stock":true},{"title":"VIP 10mg","offer_id":52038353977634,"sku":"VIP10","price":213.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1008\/2805\/3794\/files\/VIP_42146d42-f514-494a-afa9-dc47109f7321.jpg?v=1783741700","url":"https:\/\/yuansensepeptide.com\/products\/vip","provider":"Yuansensetech™","version":"1.0","type":"link"}