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Ara-290

Ara-290

$88.00
$88.00
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Product Description

Overview
ARA-290 is a synthetic research peptide, an 11-amino acid engineered to mimic the three-dimensional structure of the helix B surface domain of erythropoietin (EPO). ARA-290 peptide is non-erythropoietic, designed to retain neuroprotective and anti-inflammatory activities while eliminating hematopoietic function. This Peptide has received Orphan Drug Designation from FDA for treatment of neuropathic pain in sarcoidosis patients and has been investigated for retinal diseases.
Mechanism of Action

ARA-290 exerts its effects through selective, high-affinity binding to the Innate Repair Receptor (IRR)—a heterodimeric receptor complex composed of the erythropoietin receptor (EPOR) and the β-common receptor (βcR/CD131). This receptor is typically expressed at low levels in healthy tissues but is upregulated in response to injury, inflammation, or metabolic stress. By selectively activating the IRR without interacting with the erythropoietic EPO-R homodimer, ARA-290 triggers a cascade of intracellular signaling events that collectively suppress inflammation, inhibit apoptosis, and promote tissue regeneration. Key downstream pathways include JAK2/STAT, PI3K/Akt, and inhibition of the NF-κB inflammatory pathway.

Research Applications
  • Neuropathic Pain and Neuropathy: Investigated for the treatment of neuropathic pain in sarcoidosis and diabetes, with clinical trials demonstrating dose-dependent reduction of allodynia and suppression of spinal microglia responses.
  • Ischemic Stroke and Neuroprotection: Studied for brain tissue protection in cerebral ischemic stroke models, providing neuroprotective effects via the β-common receptor without causing erythropoiesis.
  • Metabolic Control and Type 2 Diabetes: Employed in research to evaluate improvement of metabolic control and neuropathic symptoms in patients with type 2 diabetes.
  • Inflammatory and Autoimmune Diseases: Investigated in models of experimental colitis, experimental autoimmune encephalomyelitis, and renal allograft injury for its anti-inflammatory and tissue-protective properties.
  • Cisplatin-Induced Nephrotoxicity: Studied for protective effects through anti-apoptotic, anti-inflammatory, and antioxidant mechanisms.
Product Specifications

CAS Number: 1208243-50-8
PubChem CID: 91810664
Molecular Formula: C₅₁H₈₄N₁₆O₂₁
Molecular Weight: 1,257.31 g/mol
Sequence: Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH (Pyr = pyroglutamic acid)
Purity: ≥ 99%
Form: Lyophilized powder
Storage: Store at ≤ -20°C in a cool, dry place, protected from light and moisture
Solubility: Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol

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Research Use Only

This product is intended for research purposes only and is not for human consumption, therapeutic use, or diagnostic applications. Please ensure compliance with all applicable regulations and institutional guidelines.