BPC157

BPC-157 is a synthetic research peptide comprising 15 amino acids with a unique non-natural sequence. BPC-157 peptide has garnered significant research interest for its cytoprotective and regenerative properties in preclinical models. This BPC157 pentadecapeptide demonstrates broad-spectrum efficacy in studies of gastrointestinal, musculoskeletal, neural, and vascular injury, making it a versatile tool for tissue repair research.

BPC-157 exerts its pharmacological effects through multiple interconnected pathways. It promotes healing by boosting growth factors and reducing inflammatory cytokines. A key mechanism involves activation of the nitric oxide (NO) system, enhancing endothelial nitric oxide synthase (eNOS) phosphorylation through the Src-Caveolin-1-eNOS pathway, which is associated with tissue repair and angiogenesis. BPC-157 also stimulates nitric oxide synthase generation and possesses free radical scavenging activity. Recent research has established a novel molecular mechanism centered on the BPC-157-FBXO22-BACH1 axis: intracellular BPC-157 engages the E3 ubiquitin ligase adaptor protein FBXO22, suppressing ubiquitination and proteasomal degradation of the transcription factor BACH1, thereby enhancing vascular endothelial cell proliferation and tube-forming capacity.

• Tissue Regeneration: Investigated for promoting repair of muscles, tendons, ligaments, bones, and soft tissues, with improved functional, structural, and biomechanical outcomes in preclinical models.
• Gastrointestinal Health: Studied for mucosal protection, wound healing, inflammatory bowel disease, and mitigation of NSAID-induced injury.
• Angiogenesis Studies: Employed to evaluate the formation of new blood vessels through the BPC-157-FBXO22-BACH1 axis.
• Ischemia-Reperfusion Injury: Used in preclinical models to assess protective effects against skeletal muscle I/R injury by attenuating oxidative stress, modulating apoptosis, and reducing inflammation.
• Inflammatory Modulation: Utilized to evaluate reduction of inflammatory cytokines and immune regulation.

CAS Number: 137525-51-0 (free base); acetate salt: 1628202-19-6
PubChem CID: 9941957
Molecular Formula: C₆₂H₉₈N₁₆O₂₂
Molecular Weight: 1,419.5 g/mol
Purity: ≥ 98% (batch-dependent; refer to Certificate of Analysis)
Sequence: H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH
Form: Lyophilized powder
Storage: Store at ≤ -20°C in a cool, dry place, protected from light and moisture
Solubility: Freely soluble in water and DMSO; prepare working solutions per laboratory protocol