Cagrilintide

Cagrilintide (AM833; NN0174-0833) is a novel, long-acting acylated analogue of the endogenous satiety hormone amylin. It functions as a dual agonist of the amylin receptor (AMYR) and the calcitonin G protein-coupled receptor (CTR). This unique mechanism allows it to significantly reduce body weight and food intake, making it a valuable tool for obesity and related metabolic disorder research. The compound is being developed for once-weekly subcutaneous administration, and is currently being investigated in clinical trials both as a monotherapy and in a fixed-dose combination with the GLP-1 receptor agonist semaglutide (CagriSema).

Cagrilintide exerts its effects by binding to and activating amylin and calcitonin receptors in key brain regions involved in appetite control, such as the area postrema and hypothalamus. This activation reduces food intake and promotes weight loss through central and peripheral mechanisms. As a long-acting analogue, it has a significantly extended half-life compared to traditional amylin analogues, reducing the need for frequent dosing.

• Obesity and Metabolic Research: Employed as a tool to study appetite regulation, energy balance, and weight loss mechanisms.
• Type 2 Diabetes: Investigated for its potential to improve glycemic control and metabolic parameters, particularly in combination with other agents.
• Combination Therapy Studies: Used to explore the synergistic effects of dual amylin/calcitonin receptor agonism with GLP-1 receptor activation.

CAS Number: 1415456-99-3
Molecular Formula: C₁₉₄H₃₁₂N₅₄O₅₉S₂
Molecular Weight: 4,409.01 g/mol
Sequence: (Eicosanedioic acid-γ-Glu)-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Pro-NH₂ (Disulfide bridge: Cys³-Cys⁸)
Purity: ≥ 99%
Form: White to off-white lyophilized powder
Storage: Store at ≤ -20°C in a cool, dry place, protected from light and moisture
Solubility: Soluble in sterile water; prepare working solutions per laboratory protocol