GHK-CU

GHK-Cu exerts its biological effects through multiple interconnected pathways. It binds to cell-surface receptors and activates intracellular pathways that promote collagen I and III synthesis, glycosaminoglycan deposition, and angiogenesis. GHK-Cu modulates the activity of thousands of human genes, essentially resetting them to a younger, healthier state. It stimulates the production of messenger RNA for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts, while exerting antioxidant effects by reducing levels of nitric oxide (NO) and reactive oxygen species (ROS) and improving superoxide dismutase (SOD) activity. The copper ion plays a critical role in its biological activity, and GHK facilitates the uptake of copper by cells.

• Wound Healing: Investigated for accelerating wound repair, serving as a chemoattractant for inflammatory and endothelial cells.
• Tissue Regeneration: Studied for promoting repair of skin, connective tissue, and extracellular matrix remodeling.
• Anti-Inflammatory and Antioxidant Research: Employed to evaluate reduction of oxidative stress and inflammatory responses.
• Hair Research: Investigated for potential effects on hair growth and follicle size.

CAS Number: 89030-95-5
PubChem CID: 71587328 (free base); also reported as 73587
Molecular Formula: C₁₄H₂₁CuN₆O₄ (copper complex); C₁₄H₂₃CuN₆O₄⁺ (free base)
Molecular Weight: 400.90–401.91 g/mol (copper complex); 402.92 g/mol (free base)
Sequence: Gly-His-Lys-Cu (GHK-Cu)
Purity: ≥ 98% (batch-dependent; refer to Certificate of Analysis)
Form: Lyophilized powder
Storage: Store at ≤ -20°C in a cool, dry place, protected from light and moisture
Solubility: Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol