GHRP-2 Acetate

GHRP-2 Acetate (Growth Hormone Releasing Peptide-2; also known as Pralmorelin, KP-102, or GPA-748) is a synthetic hexapeptide belonging to the family of growth hormone secretagogues (GHSs). It functions as a potent agonist of the ghrelin/growth hormone secretagogue receptor (GHS-R), stimulating the endogenous release of growth hormone (GH) from the pituitary gland. The compound is available as the acetate salt form for research applications and has been investigated as a diagnostic agent for growth hormone deficiency and for the treatment of pituitary disorders.

GHRP-2 exerts its effects by selectively binding to and activating the growth hormone secretagogue receptor type 1a (GHS-R1a), a G protein-coupled receptor expressed primarily in the hypothalamus and pituitary gland. Upon receptor activation, GHRP-2 stimulates the synthesis and pulsatile release of growth hormone from somatotroph cells in the anterior pituitary. The compound produces a rapid and significant plasma GH response, with peak concentrations occurring around 15 minutes and not exceeding 60 minutes after administration. GHRP-2 also exhibits a slight stimulatory effect on prolactin, ACTH, and cortisol levels.

• Growth Hormone Axis Research: Employed as a potent tool to study GHSR signaling, GH secretion dynamics, and the physiological regulation of the hypothalamic-pituitary-somatotropic axis.
• Diagnostic Agent Research: Investigated as a diagnostic agent for growth hormone deficiency and for the study of pituitary disorders.
• Metabolic and Body Composition Studies: Studied for its role in promoting lean body mass and reducing adiposity through GH-mediated mechanisms.
• Anti-Inflammatory Research: Investigated for anti-inflammatory effects, with studies demonstrating efficacy in arthritic rat models.
• Endocrinology: Utilized to evaluate the physiological effects of GH modulation on metabolic parameters.

CAS Number: 158861-67-7
Molecular Formula: C₄₅H₅₅N₉O₆
Molecular Weight: 817.97–818.0 g/mol
Sequence: H-D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂
Purity: ≥ 99%
Form: Lyophilized powder
Storage: Store at ≤ -20°C in a cool, dry place, protected from light and moisture
Solubility: Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol