GKP70 (BPC+GHK-Cu+KPV)

GKP70 is a research peptide blend combining three well-characterized synthetic peptides—BPC-157 (10 mg), GHK-Cu (50 mg), and KPV (10 mg)—in a single lyophilized vial. BPC-157 (Body Protection Compound-157) is a synthetic 15-amino acid pentadecapeptide derived from a native gastric juice protein, widely studied for its broad-spectrum tissue protection and repair properties. GHK-Cu (copper tripeptide-1) is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine (GHK), found in human plasma, with the copper ion playing a critical role in its biological activity. KPV is a synthetic tripeptide (Lys-Pro-Val) corresponding to the C-terminal fragment of alpha-melanocyte-stimulating hormone (α-MSH), known for its potent anti-inflammatory and immunomodulatory properties. This blend is designed to support experimental workflows investigating tissue regeneration, anti-inflammatory processes, wound healing, and recovery.

GKP70 exerts its effects through the synergistic action of its three components. BPC-157 modulates multiple pathways involved in cell growth, proliferation, and angiogenesis while reducing inflammatory cytokines. It promotes nitric oxide (NO) synthesis, enhances growth hormone receptor expression, and drives angiogenesis through the BPC-157-FBXO22-BACH1 axis. GHK-Cu acts as a potent modulator of cellular activity, stimulating collagen production, exerting antioxidant and anti-inflammatory effects, and promoting the expression of trophic and angiogenic factors. KPV exerts potent anti-inflammatory effects through non-classical, receptor-independent mechanisms, primarily through inhibition of interleukin-1β (IL-1β) functions and suppression of nuclear factor kappa-B (NF-κB) signaling, thereby blocking the transcription of pro-inflammatory genes.

• Tissue Regeneration: Investigated for promoting repair of muscles, tendons, ligaments, skin, and soft tissues through synergistic mechanisms.
• Anti-Inflammatory Research: Employed to evaluate modulation of inflammatory cytokines, NF-κB signaling, and immune responses.
• Angiogenesis Studies: Utilized to assess the formation of new blood vessels.
• Wound Healing: Studied for enhancing keratinocyte migration, collagen deposition, and dermal tissue repair.
• Antioxidant Research: Explored for reducing oxidative stress through GHK-Cu-mediated mechanisms.

Peptide Content: BPC-157 (10 mg), GHK-Cu (50 mg), KPV (10 mg) per vial
CAS Number: 137525-51-0 (BPC-157 free base); 89030-95-5 (GHK-Cu); 67727-97-3 (KPV)
Molecular Formula: C₆₂H₉₈N₁₆O₂₂ (BPC-157); C₁₄H₂₂CuN₆O₄ (GHK-Cu); C₁₆H₃₀N₄O₄ (KPV)
Molecular Weight: 1,419.5 g/mol (BPC-157); 400.91 g/mol (GHK-Cu copper complex); 342.43 g/mol (KPV)
Purity: ≥ 99%
Form: Lyophilized powder
Storage: Store at ≤ -20°C in a cool, dry place, protected from light and moisture
Solubility: Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol