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Glutathione

Glutathione

$49.00
$49.00
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Product Description

Overview
Glutathione is a synthetic research peptide, a small molecule thiol tripeptide composed of glutamic acid, cysteine, and glycine. Glutathione peptide serves as a key endogenous antioxidant found ubiquitously in animals, plants, and microorganisms, with its GSH/GSSG ratio serving as a critical indicator of cellular redox status. This Glutathione tripeptide features an unusual gamma-peptide bond protecting it from protease degradation and is widely studied for antioxidant and detoxification research.
Mechanism of Action

Glutathione exerts its effects through multiple interconnected mechanisms. As a potent antioxidant, GSH directly donates electrons to neutralize free radicals, reactive oxygen species (ROS), peroxides, and heavy metals. It serves as a cofactor for the enzyme glutathione peroxidase, which reduces peroxides, and participates in leukotriene synthesis. GSH conjugates to drugs and lipophilic toxins in the liver during biotransformation, making them more soluble for excretion via bile. It is involved in protein disulfide bond rearrangement, amino acid transport, and the recycling of vitamins E and C. GSH also modifies protein function through a process known as S-glutathionylation, independent of its classical antioxidant effects.

Research Applications
  • Antioxidant and Oxidative Stress Research: Investigated as a primary intracellular antioxidant for studying redox balance, ROS scavenging, and protection against oxidative damage in various disease models.
  • Detoxification Studies: Employed in research on liver detoxification, drug metabolism, and heavy metal chelation.
  • Immunology and Inflammation: Studied for its role in immune modulation and reducing inflammatory responses.
  • Oncology Research: Explored for its dual role in cancer—as a protective agent against oxidative stress and as a target for therapeutic intervention.
  • Metabolic and Liver Disease: Investigated in preclinical models for managing liver diseases, metabolic disorders, and oxidative stress-related conditions.
  • Food and Cosmetic Science: Utilized as an antibrowning agent in food preservation and as an active ingredient in cosmetic formulations.
Product Specifications

CAS Number: 70-18-8
PubChem CID: 124886
Molecular Formula: C₁₀H₁₇N₃O₆S
Molecular Weight: 307.33 g/mol
Sequence: γ-Glu-Cys-Gly (H-Glu(Cys-Gly)-OH)
Purity: ≥ 98% (batch-dependent; refer to Certificate of Analysis)
Appearance: White to off-white crystalline powder
Storage: Store at 2–8°C in a cool, dry place, protected from light; aqueous solutions should be prepared fresh or stored at -20°C under inert gas
Solubility: Freely soluble in water (50 mg/mL), dilute alcohol, liquid ammonia, and DMF

 

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Research Use Only

This product is intended for research purposes only and is not for human consumption, therapeutic use, or diagnostic applications. Please ensure compliance with all applicable regulations and institutional guidelines.