LIPO-C B12

LIPO-C (with B12) is a research-grade compounded lipotropic formulation supplied in a sterile liquid solution for laboratory and scientific research applications. The formulation combines lipotropic agents—methionine, inositol, and choline (MIC)—with L-carnitine, cyanocobalamin (Vitamin B12), and additional cofactors that support hepatic fat metabolism, methylation pathways, and cellular energy production. This complete formulation is designed for controlled in vitro studies and biochemical compound analysis requiring B12 supplementation.

LIPO-C exerts its effects through the synergistic action of its core components on hepatic lipid metabolism and cellular energy pathways. Methionine serves as a methyl donor, converting to S-adenosylmethionine (SAMe) in hepatocytes, which is required for phosphatidylcholine synthesis—the structural backbone of VLDL particles that package triglycerides for export from the liver. Choline directly supports phosphatidylcholine production through the CDP-choline pathway, providing a redundant mechanism that remains functional even in patients with MTHFR polymorphisms affecting SAMe synthesis. Inositol functions as a secondary messenger in insulin receptor signaling, modulating glucose uptake and reducing insulin resistance. L-Carnitine supports fatty-acid transport into mitochondria for β-oxidation. Vitamin B12 (cyanocobalamin) acts as a cofactor for methionine synthase, facilitating the remethylation of homocysteine to methionine, thereby supporting the methylation cycle and enhancing the lipotropic effects. The mechanism is hepatocentric—preventing hepatic triglyceride accumulation rather than triggering systemic lipolysis in adipose tissue.

• Hepatic Lipid Metabolism: Investigated for studying hepatic fat processing, VLDL export, and lipid clearance mechanisms with B12-mediated methylation support.
• Methylation Pathway Research: Employed to evaluate methyl donor utilization, SAMe synthesis, and homocysteine metabolism in the presence of B12 cofactor.
• Insulin Signaling and Glucose Metabolism: Studied for inositol-mediated modulation of insulin receptor signaling and glucose uptake.
• Mitochondrial Fatty Acid Oxidation: Utilized to assess L-carnitine-mediated fatty-acid transport and mitochondrial energy production.
• Combination Therapy Research: Explored in conjunction with GLP-1 receptor agonists to evaluate complementary pathways in appetite signaling and fat mobilization.

Form: Sterile liquid solution (with B12)
Core Components: Methionine, Inositol, Choline (MIC complex)
Additional Components: Vitamin B12 (cyanocobalamin), L-Carnitine, Pyridoxine (B6)
Purity: ≥ 99%
Storage: Store at ≤ -20°C in a cool, dry place, protected from light and moisture
Solubility: Supplied as sterile liquid solution; prepare working solutions per laboratory protocol