LIPO-C (without B12)

LIPO-C (without B12) is a research-grade compounded lipotropic formulation supplied in a sterile liquid solution for laboratory and scientific research applications. The formulation combines lipotropic agents—methionine, inositol, and choline (MIC)—with L-carnitine and additional cofactors that support hepatic fat metabolism, methylation pathways, and cellular energy production, specifically formulated without cyanocobalamin (Vitamin B12) for research protocols requiring B12-free conditions. LIPO-C is designed for controlled in vitro studies and biochemical compound analysis.

LIPO-C exerts its effects through the synergistic action of its core components on hepatic lipid metabolism and cellular energy pathways. Methionine serves as a methyl donor, converting to S-adenosylmethionine (SAMe) in hepatocytes, which is required for phosphatidylcholine synthesis—the structural backbone of VLDL particles that package triglycerides for export from the liver. Choline directly supports phosphatidylcholine production through the CDP-choline pathway, providing a redundant mechanism that remains functional even in patients with MTHFR polymorphisms affecting SAMe synthesis. Inositol functions as a secondary messenger in insulin receptor signaling, modulating glucose uptake and reducing insulin resistance. L-Carnitine supports fatty-acid transport into mitochondria for β-oxidation. The mechanism is hepatocentric—preventing hepatic triglyceride accumulation rather than triggering systemic lipolysis in adipose tissue.

• Hepatic Lipid Metabolism: Investigated for studying hepatic fat processing, VLDL export, and lipid clearance mechanisms, particularly in the absence of B12-mediated pathways.
• Methylation Pathway Research: Employed to evaluate methyl donor utilization, SAMe synthesis, and MTHFR-related metabolic variations without confounding effects from B12 supplementation.
• Insulin Signaling and Glucose Metabolism: Studied for inositol-mediated modulation of insulin receptor signaling and glucose uptake.
• Mitochondrial Fatty Acid Oxidation: Utilized to assess L-carnitine-mediated fatty-acid transport and mitochondrial energy production.
• Combination Therapy Research: Explored in conjunction with GLP-1 receptor agonists to evaluate complementary pathways in appetite signaling and fat mobilization.

Form: Sterile liquid solution (B12-free formulation)
Core Components: Methionine, Inositol, Choline (MIC complex)
Additional Components: L-Carnitine, Pyridoxine (B6)
Purity: ≥ 99%
Storage: Store at ≤ -20°C in a cool, dry place, protected from light and moisture
Solubility: Supplied as sterile liquid solution; prepare working solutions per laboratory protocol