PT-141

PT-141 exerts its effects by binding to and activating multiple melanocortin receptors, including MC1R, MC3R, MC4R, and MC5R, which are expressed primarily in the central nervous system. Its potency order is MC1R > MC4R > MC3R > MC5R > MC2R. Activation of MC4R in hypothalamic and limbic brain regions increases dopamine release and modulates pathways associated with sexual desire and arousal.

• Sexual Dysfunction Research: Investigated for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women and erectile dysfunction in men.
• Neuroendocrinology: Employed as a tool to study melanocortin receptor signaling, dopamine release, and central nervous system pathways regulating sexual behavior.
• Hemorrhagic Shock and Reperfusion Injury: Studied for its potential protective effects in preclinical models.

CAS Number: 189691-06-3 (free base); 1607799-13-2 (acetate salt)
PubChem CID: 9941379 (free base); 91971505 (acetate salt)
Molecular Formula: C₅₀H₆₈N₁₄O₁₀ (free base); C₅₂H₇₂N₁₄O₁₂ (acetate salt)
Molecular Weight: 1,025.18 g/mol (free base); 1,085.22 g/mol (acetate salt)
Sequence: Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH
Purity: ≥ 98% (batch-dependent; refer to Certificate of Analysis)
Form: White to off-white lyophilized powder
Storage: Store at ≤ -20°C in a cool, dry place, protected from light and moisture
Solubility: Soluble in sterile water (≥100 µg/mL), DMSO, and PBS (pH 7.2); prepare working solutions per laboratory protocol