CJC-1295 With DAC

CJC-1295 with DAC (Drug Affinity Complex), also known as DAC:GRF, is a synthetic analogue of growth hormone-releasing hormone (GHRH) developed by ConjuChem Biotechnologies. It is a tetrasubstituted 30-amino acid peptide analogue of GHRH, featuring a C-terminal Drug Affinity Complex moiety—a lysine linker conjugated to maleimidopropionic acid (MPA)—that enables selective binding to circulating albumin. This DAC technology significantly extends the compound's half-life to approximately 6–8 days, compared to ~30 minutes for the non-DAC version, establishing it as a long-acting GHRH analogue.

CJC-1295 with DAC exerts its effects by binding to the growth hormone-releasing hormone receptor (GHRH-R) on somatotroph cells in the anterior pituitary gland. This receptor activation stimulates the synthesis and release of endogenous growth hormone (GH) in a sustained manner. The Drug Affinity Complex moiety enables the peptide to covalently bind to serum albumin following subcutaneous administration, protecting it from enzymatic degradation and significantly prolonging its half-life. The compound incorporates four amino acid substitutions—D-Ala at position 2 (to prevent DPP-IV cleavage), Gln at position 8 (to reduce asparagine rearrangement), Ala at position 15 (to enhance bioactivity), and Leu at position 27 (to prevent methionine oxidation)—which further enhance its stability and bioactivity.

• Growth Hormone Axis Research: Employed to study sustained GH secretion dynamics, GHRH receptor signaling, and the physiological regulation of the hypothalamic-pituitary-somatotropic axis.
• Metabolic and Body Composition Studies: Investigated for its role in lipid metabolism, protein synthesis, and body composition regulation.
• Endocrinology: Utilized to evaluate the effects of prolonged GH elevation on IGF-1 production and metabolic parameters.
• Aging and Gerontology Research: Explored in the context of age-related metabolic decline and healthy aging.

CAS Number: 446262-90-4
PubChem CID: 16129620
Molecular Formula: C₁₆₅H₂₆₉N₄₇O₄₆
Molecular Weight: 3,647.19–3,647.25 g/mol
Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-LysLys(Maleimidopropionyl)-NH₂
Purity: ≥ 99%
Form: Lyophilized powder
Storage: Store at ≤ -20°C in a cool, dry place, protected from light and moisture
Solubility: Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol