CJC-1295 Without DAC

CJC-1295 without DAC (also known as Modified GRF 1-29, CJC-1295-no DAC, or GHRH 1-29-NH2) is a synthetic 30-amino acid peptide analogue of growth hormone-releasing hormone (GHRH). Unlike the DAC (Drug Affinity Complex) version, this peptide does not contain a lysine-based linker that enables binding to serum albumin. As a result, CJC-1295 without DAC has a shorter half-life and promotes a more physiologic, pulsatile release of growth hormone, aligning with the body's natural secretory pattern. The compound is widely studied in endocrinology research as a tool for investigating the growth hormone axis.

CJC-1295 without DAC acts as a potent agonist of the growth hormone-releasing hormone receptor (GHRH-R) in the pituitary gland. Upon receptor binding, it stimulates the synthesis and pulsatile secretion of growth hormone (GH), which in turn elevates circulating levels of insulin-like growth factor 1 (IGF-1). The absence of the DAC moiety results in a shorter duration of action compared to the DAC-conjugated version, allowing for more targeted study of acute GH release dynamics without the sustained "GH bleed" associated with long-acting analogues.

• Endocrinology and GH-Axis Research: Employed as a research tool to study the complex interactions between GHRH stimulation, GH secretion, and downstream physiological outcomes.
• Metabolic Studies: Investigated for its role in lipid metabolism, including potential effects on fat reduction and metabolic regulation.
• Muscle and Recovery Research: Studied in preclinical models for its potential to support muscle function, particularly in combination with other growth hormone secretagogues.
• Combination Studies: Frequently utilized alongside GHRP (Growth Hormone Releasing Peptides) such as Ipamorelin to evaluate synergistic effects on the GH axis.

CAS Number: 863288-34-0 (acetate salt); also reported as 446036-97-1 (free base)
Molecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight: 3,367.9 g/mol
Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂
Purity: ≥ 99% 
Form: Lyophilized powder
Storage: Store at ≤ -20°C in a cool, dry place, protected from light and moisture
Solubility: Soluble in sterile water and DMSO; prepare working solutions per laboratory protocol